ArticleInternational journal of nanomedicine2020
Polyphenol-Conjugated Bimetallic Au@AgNPs for Improved Wound Healing.
Article in International journal of nanomedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- The impact of resveratrol on skin wound healing, scarring, and aging.International wound journal · 2022Pooled it
- Polydatin Delivery Systems and Nanomedicine: Pharmacology, Preclinical Evidence, and Translation.Pharmaceutics · 2026Review
- Unlocking the Potential Use of Berry Anthocyanins as Pharmaceutical Excipients and Nanocarriers: Evidence from the Last Decades.International journal of molecular sciences · 2026Review
- Polyphenol-functionalized silver nanoparticles promote differential remineralization and reinforcement of demineralized dentin.Journal of applied oral science : revista FOB · 2026Article
- Therapeutic Potential of Chitosan-Based and Related Nanocomposite Systems in Wound Management: A Review.International journal of molecular sciences · 2025Review
- Proanthocyanidins as Therapeutic Agents in Inflammation-Related Skin Disorders.International journal of molecular sciences · 2025Review
- Leveraging crude extracts from European tree bark to combat oxidative stress, enhance wound healing, and inhibit pathogenic bacterial growth.Scientific reports · 2025Article
- Exploration of Suitable Conditions for Shoot Proliferation and Rooting ofLife (Basel, Switzerland) · 2025Article
- A Comprehensive Review on Polyphenols based Nanovesicular System for Topical Delivery.Current drug delivery · 2025Review
- RETRACTED: The effect of biosynthesized silver nanoparticles on Pseudomonas aeruginosa-infected dogs wounds.PloS one · 2025Article
- Green Tea Catechins and Skin Health.Antioxidants (Basel, Switzerland) · 2024Review
- Enhancing Antibiotic Efficacy with Natural Compounds: Synergistic Activity of Tannic Acid and Nerol with Commercial Antibiotics against Pathogenic Bacteria.Plants (Basel, Switzerland) · 2024Article
- Greener healing: sustainable nanotechnology for advanced wound care.Discover nano · 2024Review
- Article
- Inhibitory Effects of Polyphenol- and Flavonoid-Enriched Rice Seed Extract on Melanogenesis in Melan-a Cells via MAPK Signaling-Mediated MITF Downregulation.International journal of molecular sciences · 2023Article
- Multimodal roles of transient receptor potential channel activation in inducing pathological tissue scarification.Frontiers in immunology · 2023Review
- Metallic elements combine with herbal compounds upload in microneedles to promote wound healing: a review.Frontiers in bioengineering and biotechnology · 2023Review
- Polydatin: Pharmacological Mechanisms, Therapeutic Targets, Biological Activities, and Health Benefits.Molecules (Basel, Switzerland) · 2022Review
- Recent Advances in the Development and Antimicrobial Applications of Metal-Phenolic Networks.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- Amazonian Guarana- and Açai-Conjugated Extracts Improve Scratched Fibroblast Healing andOxidative medicine and cellular longevity · 2022Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPolyphenols possess antioxidant, anti-inflammatory and antimicrobial properties and have been used in the treatment of skin wounds and burns. We previously showed that tannic acid-modified AgNPs sized >26 nm promote wound healing, while tannic acid-modified AgNPs sized 13 nm can elicit strong local inflammatory response. In this study, we tested bimetallic Au@AgNPs sized 30 nm modified with selected flavonoid and non-flavonoid compounds for wound healing applications.
methodsBimetallic Au@AgNPs were obtained by growing an Ag layer on AuNPs and further modified with selected polyphenols. After toxicity tests and in vitro scratch assay in HaCaT cells, modified lymph node assay as well as the mouse splint wound model were further used to access the wound healing potential of selected non-toxic modifications.
resultsTannic acid, gallic acid, polydatin, resveratrol, catechin, epicatechin, epigallocatechin, epicatechin gallate, epigallocatechin gallate and procyanidin B2 used to modify Au@AgNPs exhibited good toxicological profiles in HaCaT cells. Au@AgNPs modified with 15 μM tannic acid, 200 μM resveratrol, 200 μM epicatechin gallate, 1000 μM gallic acid and 200 μM procyanidin B2 induced wound healing in vivo and did not lead to the local irritation or inflammation. Tannic acid-modified Au@AgNPs induced epithelial-to-mesenchymal transition (EMT) - like re-epithelialization, while other polyphenol modifications of Au@AgNPs acted through proliferation and wound closure.
conclusionBimetallic Au@AgNPs can be used as a basis for modification with selected polyphenols for topical uses. In addition, we have demonstrated that particular polyphenols used to modify bimetallic nanoparticles may show different effects upon different stages of wound healing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.