ArticlePloS one2020
Risk factors predicting osteosarcopenia in postmenopausal women with osteoporosis: A retrospective study.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Association between osteosarcopenia and frailty in older adults: a systematic review and meta-analysis.BMC geriatrics · 2026Pooled it
- Global epidemiological features and impact of osteosarcopenia: A comprehensive meta-analysis and systematic review.Journal of cachexia, sarcopenia and muscle · 2024Pooled it
- Prevalence and risk factors of osteosarcopenia: a systematic review and meta-analysis.BMC geriatrics · 2023Pooled it
- Association between stride length variability and osteosarcopenia in community-dwelling older women: a cross-sectional study.BMC geriatrics · 2026Article
- The Rising Burden of Osteosarcopenia in Older Adults: A Narrative Review of Pathophysiology, Diagnostic Challenges, and Therapeutic Perspectives.Health science reports · 2026Article
- Association of serum periostin with bone microarchitecture, muscle mass and function in Chinese postmenopausal women.Frontiers in endocrinology · 2026Article
- Clinical evaluation of therapeutic efficacy of Teriparatide in osteoporotic patients with vertebral degeneration.Journal of orthopaedics · 2025Article
- Ultrasound evaluation of muscles in older patients with metabolıc syndrome.Irish journal of medical science · 2025Article
- Epigenetic Dysregulation and Osteocyte Senescence: Convergent Drivers of Osteosarcopenia in Aging Bone and Muscle.Aging and disease · 2025Review
- Association between bone mineral density T-score and respiratory sarcopenia in older adults.Frontiers in medicine · 2025Article
- The association between computed tomography-based osteosarcopenia and osteoporotic vertebral fractures: a longitudinal study.Journal of endocrinological investigation · 2025Article
- The efficacy of nutritional screening indexes in predicting the incidence of osteosarcopenia and major osteoporotic fracture in the elderly.Journal of bone and mineral metabolism · 2024Article
- Prognostic impact of osteosarcopenia in patients undergoing pancreatic resection for pancreatic ductal adenocarcinoma.Langenbeck's archives of surgery · 2024Article
- Analysis of related factors for sarco-osteoporosis in middle-aged and elderly inpatients and development and validation of a nomogram.BMC musculoskeletal disorders · 2024Article
- Relationship between sacral-abdominal wall distance, movement performance, and spinal alignment in osteoporosis: a retrospective study.BMC geriatrics · 2024Article
- Article
- Denosumab's Therapeutic Effect for Future Osteosarcopenia Therapy : A Systematic Review and Meta-Analysis.Annals of geriatric medicine and research · 2023Article
- Features of older community-dwelling adults with osteosarcopenia requiring support or care.Journal of physical therapy science · 2022Article
- Osteosarcopenia, the co-existence of osteoporosis and sarcopenia, is associated with social frailty in older adults.Aging clinical and experimental research · 2022Article
- Associations of osteoporosis and sarcopenia with frailty and multimorbidity among participants of the Hertfordshire Cohort Study.Journal of cachexia, sarcopenia and muscle · 2022Article
Corrections and comments
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is growing interest in "osteosarcopenia" as the coexistence of osteoporosis and sarcopenia exacerbates negative outcomes. However, limited information is available regarding the risk factors of osteosarcopenia development in patients with osteoporosis. Therefore, we retrospectively reviewed 276 consecutive patients with postmenopausal osteoporosis who regularly visited Showa University Hospital. Patients were eligible for the study if they were ≥65 years of age and underwent dual-energy X-ray absorptiometry, blood sampling, and physical performance assessment. Patients were divided into the osteosarcopenia and osteoporosis alone groups according to the diagnostic criteria of the Asian Working Group for Sarcopenia. Of the 276 patients with osteoporosis, 54 patients (19.6%) had osteosarcopenia. Patients in the osteosarcopenia group had a greater risk of frailty than did those in the osteoporosis alone group (odds ratio 2.33; 95% confidence interval, 1.13-4.80, P = 0.028). Low body mass index seemed to be the strongest factor related to the development of osteosarcopenia, and none of the patients in the osteosarcopenia group were obese (BMI ≥27.5 kg/m2). Multiple logistic analyses revealed that patients aged 65-74 years who had comorbidities such as kidney dysfunction and high levels of HbA1c were at risk of developing osteosarcopenia. Thus, we strongly recommend the assessment of the key components of the diagnosis of osteosarcopenia in an osteoporosis clinic for patients with low body mass index. Furthermore, appropriate assessments, including comorbidities, will help in identifying patients at greater risk of developing osteosarcopenia.
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