ArticlePloS one2020
Spectrum of antibiotic resistant bacteria and fungi isolated from chronically infected wounds in a rural district hospital in Ghana.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Causes of Bacterial Infections and Antibiotic Resistance Profiles in Patients with Chronic Wounds.Microorganisms · 2026Article
- Molecular Characterisation of Fungi Populations in the Chronic Wounds of Filarial Lymphedema Patients in Southern Ghana: A Cross-Sectional Study.Health science reports · 2025Article
- Nanoparticle-Enhanced Collagen Hydrogels for Chronic Wound Management.Journal of functional biomaterials · 2025Article
- Mapping antibiotic resistance in Ghana: a narrative review of regional variations in antibiotic-resistant ESKAPEE pathogens.Frontiers in microbiology · 2025Review
- Biofilm formation and antibiogram profile of bacteria from infected wounds in a general hospital in southern Ethiopia.Scientific reports · 2024Article
- A Systematic Review on Antimicrobial Resistance in Ghana from a One Health Perspective.Antibiotics (Basel, Switzerland) · 2024Review
- Antiseptic, Hemostatic, and Wound Activity of Poly(vinylpyrrolidone)-Iodine Gel with Trimethyl Chitosan.International journal of molecular sciences · 2024Article
- The Most Common Multi-Drug Resistant Bacteria Associated with Hospital Infections, in Urmia, Iran.Iranian journal of pathology · 2024Article
- Antimicrobial resistance in bacterial wound, skin, soft tissue and surgical site infections in Central, Eastern, Southern and Western Africa: A systematic review and meta-analysis.PLOS global public health · 2024Article
- Colonizing microbiota is associated with clinical outcomes in diabetic wound healing.Advanced drug delivery reviews · 2023Review
- Biofilms in Chronic Wound Infections: Innovative Antimicrobial Approaches Using the In Vitro Lubbock Chronic Wound Biofilm Model.International journal of molecular sciences · 2023Review
- Escherichia coli BarA-UvrY regulates the pks island and kills Staphylococci via the genotoxin colibactin during interspecies competition.PLoS pathogens · 2022Article
- Article
- Bacterial Interactions in the Context of Chronic Wound Biofilm: A Review.Microorganisms · 2022Review
- Epidemiology of Plasmids inAntibiotics (Basel, Switzerland) · 2022Article
- Microbial Species Isolated from Infected Wounds and Antimicrobial Resistance Analysis: Data Emerging from a Three-Years Retrospective Study.Antibiotics (Basel, Switzerland) · 2021Article
- Clonal Clusters, Molecular Resistance Mechanisms and Virulence Factors of Gram-Negative Bacteria Isolated from Chronic Wounds in Ghana.Antibiotics (Basel, Switzerland) · 2021Article
- High Prevalence of Carbapenemase-ProducingMicroorganisms · 2021Article
- Molecular Characterization ofMicroorganisms · 2020Article
Corrections and comments
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Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic infected wounds are generally difficult to manage and treatment can be particularly challenging in resource-limited settings where diagnostic testing is not readily available. In this study, the epidemiology of microbial pathogens in chronically infected wounds in rural Ghana was assessed to support therapeutic choices for physicians.
methodsCulture-based bacterial diagnostics including antimicrobial resistance testing were performed on samples collected from patients with chronic wounds at a hospital in Asante Akim North Municipality, Ghana. Fungal detection was performed by broad-range fungal PCR and sequencing of amplicons.
resultsIn total, 105 patients were enrolled in the study, from which 207 potential bacterial pathogens were isolated. Enterobacteriaceae (n = 84, 41%) constituted the most frequently isolated group of pathogens. On species level, Pseudomonas aeruginosa (n = 50, 24%) and Staphylococcus aureus (n = 28, 14%) were predominant. High resistance rates were documented, comprising 29% methicillin resistance in S. aureus as well as resistance to 3rd generation cephalosporins and fluoroquinolones in 33% and 58% of Enterobacteriaceae, respectively. One P. aeruginosa strain with carbapenem resistance was identified. The most frequently detected fungi were Candida tropicalis.
conclusionsThe pathogen distribution in chronic wounds in rural Ghana matched the internationally observed patterns with a predominance of P. aeruginosa and S. aureus. Very high resistance rates discourage antibiotic therapy but suggest an urgent need for microbiological diagnostic approaches, including antimicrobial resistance testing to guide the management of patients with chronic wounds in Ghana.
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