Observational studyPloS one2020
The Mont Blanc Study: The effect of altitude on intra ocular pressure and central corneal thickness.
Observational study in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 13 citations in OpenAlex.
- Effects of Daily Ambient Temperature on Intraocular Pressure: A Time-Series Analysis Using Generalized Additive and Distributed Lag Nonlinear Models.Investigative ophthalmology & visual science · 2025Article
- Effects of ambient atmospheric pressure on intraocular pressure measured using a Goldman applanation tonometer in normal eyes under ordinary conditions.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- New insights into changes in ocular structural parameters in simulated hypobaric hypoxia.BMJ open ophthalmology · 2025Article
- High-altitude effect on corneal endothelial cells and prognosis in patients with cataract surgeries: a propensity score matched analysis.International journal of ophthalmology · 2025Article
- Influence of meteorological factors on intraocular pressure variability using a large-scale cohort.Scientific reports · 2024Article
- Glaucoma burden and its profile in a tertiary care centre of North-East India: A retrospective hospital-based study.Journal of family medicine and primary care · 2024Article
- Comparison of central corneal thickness measured by automatic and manual analysis of optical coherence tomography.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Article
- Influence of hypobaric hypoxic conditions on ocular structure and biological function at high attitudes: a narrative review.Frontiers in neuroscience · 2023Review
- Physiology-Enhanced Data Analytics to Evaluate the Effect of Altitude on Intraocular Pressure and Ocular Hemodynamics.Photonics · 2022Article
- Effects of acute stress, general anesthetics, tonometry, and temperature on intraocular pressure in rats.Experimental eye research · 2021Article
- Relationship between Central Corneal Thickness and Endothelial Cell Density in Individuals with Primary Glaucoma and the General Population Living at High Altitudes.Journal of current ophthalmologyArticle
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the Mont Blanc Study was to investigate the relationship between intraocular pressure (IOP), central corneal thickness (CCT), and altitude in healthy subjects. Thirty-three eyes of 33 healthy volunteers (mean age: 24.8 years, 17 females) had their IOP measured with Perkins and I-Care tonometers and their CCT using ultrasound pachymetry at three locations in Italy with different altitudes: Pavia, (PV), 77 meters above sea level (a.s.l); Courmayeur (CM), 1300 meters a.s.l; Pointe Helbronner (PH), 3466 meters a.s.l.). The measurements were performed at 9 am, 11 am, 1 pm and 3 pm (±30') in indoor settings (mean temperature of 19°C) in PV and PH. At 9 am, CCT and IOP were measured outdoor (mean temperature of -1.4°C) at PH. The mean values of the IOP curve decreased from PV to PH with the Perkins (p = 0.02) and I-Care tonometers (p = 0.001). Instead, CCT increased upon ascension from PV to PH (p = 0.01), and from CM to PH (p = 0.002). When exposed to sub-zero temperature, the IOP increased (p<0.001), while the CCT did not change (p = 0.30). The results suggest that IOP significantly decreased and CCT significantly increased upon ascension from the sea level to higher altitudes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.