ArticlePloS one2020
Rapid genotyping protocol to improve dengue virus serotype 2 survey in Lao PDR.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Epidemiological, virological, and clinical characteristics of dengue in the Lao People's Democratic Republic, 2022-2023: a cross-sectional study.Tropical medicine and health · 2026Article
- Dengue dynamics beyond biological factors: Revealing the nexus between urbanisation planning, and mobilities in Vientiane, Lao PDR.PLoS neglected tropical diseases · 2025Article
- Genomic Characterization of Circulating Dengue Virus, Ethiopia, 2022-2023.Emerging infectious diseases · 2025Article
- Molecular Epidemiology of Dengue Viruses in Lao People's Democratic Republic, 2020-2023.Microorganisms · 2025Article
- A Six Years (2010-2016) Longitudinal Survey of the Four Serotypes of Dengue Viruses in Lao PDR.Microorganisms · 2023Article
- Article
- Using Background Sequencing Data to Anticipate DENV-1 Circulation in the Lao PDR.Microorganisms · 2021Article
- Trends of the Dengue Serotype-4 Circulation with Epidemiological, Phylogenetic, and Entomological Insights in Lao PDR between 2015 and 2019.Pathogens (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dengue fever is one of the major public health problems in Lao PDR. Over the last decade, dengue virus (DENV) epidemics were characterized by a novel predominant serotype accompanied by at least two other serotypes. Since 2008, DENV-2 circulated at a low level in Lao PDR but its epidemiologic profile changed at the end of 2018. Indeed, the number of confirmed DENV-2 cases suddenly increased in October 2018 and DENV-2 became predominant at the country level in early 2019. We developed a Genotype Screening Protocol (GSP) to determine the origin(s) of the Lao DENV-2 and study their genetic polymorphism. With a good correlation with full envelope gene sequencing data, this molecular epidemiology tool evidence the co-circulation of two highly polymorphic DENV-2 genotypes, i.e. Asian I and Cosmopolitan genotypes, over the last five years, suggesting multiple introductions of DENV-2 in the country. GSP approach provides relevant first line information that may help countries with limited laboratory resources to reinforce their capabilities to DENV-2 and to follow the epidemics progresses and assess situations at the regional level.
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