Evidence map›Paper›PMID 32764745›Full record

ArticlePLoS computational biology2020

Achieving stable dynamics in neural circuits.

Leo Kozachkov, Mikael Lundqvist, Jean-Jacques Slotine, Earl K Miller

Abstract read
In one paragraph

Article in PLoS computational biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Brain-like hardware, do we need it?Frontiers in neuroscience · 2024
    Review
  7. Article
  8. Adaptive control of synaptic plasticity integrates micro- and macroscopic network function.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
    Review
  9. Unraveling the mysteries of dendritic spine dynamics: Five key principles shaping memory and cognition.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2023
    Article
  10. Article
  11. The Continuity of Context: A Role for the Hippocampus.Trends in cognitive sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Leo KozachkovThe Picower Institute for Learning & Memory, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, United States of America.ORCID 0000-0003-4330-1201
Mikael LundqvistThe Picower Institute for Learning & Memory, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, United States of America.ORCID 0000-0003-1011-5234
Jean-Jacques SlotineThe Picower Institute for Learning & Memory, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, United States of America.
Earl K MillerThe Picower Institute for Learning & Memory, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, United States of America.ORCID 0000-0002-0582-6958

Funding

Cortical Circuits for Attention and DecisionsR37MH087027 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI MILLER, EARL K · 2010 to 2019
$4.7M
NIMH NIH HHS R37 MH087027
6 · The paper itself

Abstract

The brain consists of many interconnected networks with time-varying, partially autonomous activity. There are multiple sources of noise and variation yet activity has to eventually converge to a stable, reproducible state (or sequence of states) for its computations to make sense. We approached this problem from a control-theory perspective by applying contraction analysis to recurrent neural networks. This allowed us to find mechanisms for achieving stability in multiple connected networks with biologically realistic dynamics, including synaptic plasticity and time-varying inputs. These mechanisms included inhibitory Hebbian plasticity, excitatory anti-Hebbian plasticity, synaptic sparsity and excitatory-inhibitory balance. Our findings shed light on how stable computations might be achieved despite biological complexity. Crucially, our analysis is not limited to analyzing the stability of fixed geometric objects in state space (e.g points, lines, planes), but rather the stability of state trajectories which may be complex and time-varying.

Indexed as

Models, NeurologicalAlgorithmsAnimalsBrainComputational BiologyComputer SimulationHumansNerve NetNeuronal Plasticity

Identifiers

PMID32764745
PMCPMC7446801

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.