Evidence map›Paper›PMID 32764711›Full record

ArticleScientific reports2020

Comprehensive N-glycosylation mapping of envelope glycoprotein from tick-borne encephalitis virus grown in human and tick cells.

Erika Lattová, Petra Straková, Petra Pokorná-Formanová, Libor Grubhoffer, Lesley Bell-Sakyi, Zbyněk Zdráhal, Martin Palus, Daniel Ruzek

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Erika LattováCentral European Institute of Technology, Masaryk University, Kamenice 5, 62500, Brno, Czech Republic. erika.lattova@gmail.com.
Petra StrakováVeterinary Research Institute, Hudcova 296/70, 62100, Brno, Czech Republic.
Petra Pokorná-FormanováVeterinary Research Institute, Hudcova 296/70, 62100, Brno, Czech Republic.
Libor GrubhofferInstitute of Parasitology, Biology Centre of the Czech Academy of Sciences, Branisovska 31, 37005, Ceske Budejovice, Czech Republic.
Lesley Bell-SakyiDepartment of Infection Biology and Microbiome, Institute of Infection, Ecological and Veterinary Sciences, University of Liverpool, 146 Brownlow Hill, Liverpool, L3 5RF, UK.
Zbyněk ZdráhalCentral European Institute of Technology, Masaryk University, Kamenice 5, 62500, Brno, Czech Republic.
Martin PalusVeterinary Research Institute, Hudcova 296/70, 62100, Brno, Czech Republic.
Daniel RuzekVeterinary Research Institute, Hudcova 296/70, 62100, Brno, Czech Republic. ruzekd@paru.cas.cz.
Veterinary Research Institute · CZCzech Academy of Sciences, Biology Centre · CZCentral European Institute of Technology · CZCentral European Institute of Technology – Masaryk University · CZUniversity of Liverpool · GB

Funding

Biotechnology and Biological Sciences Research Council BB/P024270/1
6 · The paper itself

Abstract

Tick-borne encephalitis virus (TBEV) is the causative agent of severe human neuroinfections that most commonly occur after a tick bite. N-Glycosylation of the TBEV envelope (E) glycoprotein is critical for virus egress in mammalian cells, but not in tick cells. In addition, glycans have been reported to mask specific antigenic sites from recognition by neutralizing antibodies. In this regard, the main purpose of our study was to investigate the profile of N-glycans linked to the E protein of TBEV when grown in human neuronal cells and compare it to the profile of virus grown in tick cells. Mass spectrometric analysis revealed significant differences in these profiles. High-mannose glycan with five mannose residues (Man

Indexed as

Amino Acid SequenceAnimalsCell Line, TumorEncephalitis Viruses, Tick-BorneGlycoproteinsGlycosylationHumansTicksViral Envelope ProteinsGlycoproteinsViral Envelope Proteins

Identifiers

PMID32764711
PMCPMC7411051
OpenAlexW3047240058

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.