ArticleInternational journal of molecular sciences2020
Age-Related Differences in the Time Course of Coagulation and Fibrinolytic Parameters in Patients with Traumatic Brain Injury.
Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Skull fractures may be associated with hyperfibrinolysis in patients with isolated traumatic brain injury.Clinical and experimental emergency medicine · 2026Article
- High-dimensional analysis of injured patients reveals distinct circulating proteomic profiles in plasma vs. whole blood resuscitation.Cell reports. Medicine · 2025Article
- Development of Machine-learning Model to Predict Anticoagulant Use and Type in Geriatric Traumatic Brain Injury Using Coagulation Parameters.Neurologia medico-chirurgica · 2025Article
- Can rotational thromboelastometry rapidly identify theragnostic targets in isolated traumatic brain injury?Emergency medicine Australasia : EMA · 2025Article
- The Association of Systemic Immune Inflammation Index (SII) and Platelet-to-Lymphocyte Ratio (PLR) on Coagulopathy and Prognosis in Patients with Traumatic Brain Injury.Journal of inflammation research · 2025Article
- Consensus on the management of traumatic brain injury in older adults: Results from a Delphi study.Brain & spine · 2025Article
- Development and validation of a nomogram for predicting mortality in patients with acute severe traumatic brain injury: A retrospective analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- The significance of admission blood lactate and fibrinogen in pediatric traumatic brain injury: a single-center clinical study.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
- Analysis of risk factors for trauma-induced coagulopathy in elderly major trauma patients.World journal of emergency medicine · 2024Article
- Neurointensive Care of Traumatic Brain Injury Patients Based on Coagulation and Fibrinolytic Parameter Monitoring.Neurologia medico-chirurgica · 2022Article
- Coagulopathy and Traumatic Brain Injury: Overview of New Diagnostic and Therapeutic Strategies.Neurologia medico-chirurgica · 2022Article
- The Clinical Differences of Patients With Traumatic Brain Injury in Plateau and Plain Areas.Frontiers in neurology · 2022Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Coagulopathy and older age are common and well-recognized risk factors for poorer outcomes in traumatic brain injury (TBI) patients; however, the relationships between coagulopathy and age remain unclear. We hypothesized that coagulation/fibrinolytic abnormalities are more pronounced in older patients and may be a factor in poorer outcomes. We retrospectively evaluated severe TBI cases in which fibrinogen and D-dimer were measured on arrival and 3-6 h after injury. Propensity score-matched analyses were performed to adjust baseline characteristics between older patients (the "elderly group," aged ≥75 y) and younger patients (the "non-elderly group," aged 16-74 y). A total of 1294 cases (elderly group: 395, non-elderly group: 899) were assessed, and propensity score matching created a matched cohort of 324 pairs. Fibrinogen on admission, the degree of reduction in fibrinogen between admission and 3-6 h post-injury, and D-dimer levels between admission and 3-6 h post-injury were significantly more abnormal in the elderly group than in the non-elderly group. On multivariate logistic regression analysis, independent risk factors for poor prognosis included low fibrinogen and high D-dimer levels on admission. Posttraumatic coagulation and fibrinolytic abnormalities are more severe in older patients, and fibrinogen and D-dimer abnormalities are negative predictive factors.
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