Evidence map›Paper›PMID 32764454›Full record

ReviewCancers2020

SARS-CoV-2 Infection and Lung Cancer: Potential Therapeutic Modalities.

Ishita Gupta, Balsam Rizeq, Eyad Elkord, Semir Vranic, Ala-Eddin Al Moustafa

Open access · goldAbstract readReview
In one paragraph

Review in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.3field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. ACE2: the node connecting the lung cancer and COVID-19.American journal of cancer research · 2024
    Review
  6. Review
  7. Links between Infections, Lung Cancer, and the Immune System.International journal of molecular sciences · 2021
    Review
  8. Article
  9. Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Ishita GuptaCollege of Medicine, QU Health, Qatar University, 2713 Doha, Qatar.ORCID 0000-0002-8627-3186
Balsam RizeqCollege of Medicine, QU Health, Qatar University, 2713 Doha, Qatar.ORCID 0000-0001-5859-3804
Eyad ElkordQatar Biomedical Research Institute & 4Hamad Bin Khalifa University, 34110 Doha, Qatar.ORCID 0000-0002-3868-0318
Semir VranicCollege of Medicine, QU Health, Qatar University, 2713 Doha, Qatar.ORCID 0000-0001-9743-7265
Ala-Eddin Al MoustafaCollege of Medicine, QU Health, Qatar University, 2713 Doha, Qatar.ORCID 0000-0003-4452-3439
Qatar University · QAHamad bin Khalifa University · QA

Funding

Qatar University QUHI-CMED-19/20-1, QUCG-CMED-20/21-2, GCC-2017-002 QU/KU and QUCG-CMED-20/21-2
6 · The paper itself

Abstract

Human coronaviruses, especially SARS-CoV-2, are emerging pandemic infectious diseases with high morbidity and mortality in certain group of patients. In general, SARS-CoV-2 causes symptoms ranging from the common cold to severe conditions accompanied by lung injury, acute respiratory distress syndrome in addition to other organs' destruction. The main impact upon SARS-CoV-2 infection is damage to alveolar and acute respiratory failure. Thus, lung cancer patients are identified as a particularly high-risk group for SARS-CoV-2 infection and its complications. On the other hand, it has been reported that SARS-CoV-2 spike (S) protein binds to angiotensin-converting enzyme 2 (ACE-2), that promotes cellular entry of this virus in concert with host proteases, principally transmembrane serine protease 2 (TMPRSS2). Today, there are no vaccines and/or effective drugs against the SARS-CoV-2 coronavirus. Thus, manipulation of key entry genes of this virus especially in lung cancer patients could be one of the best approaches to manage SARS-CoV-2 infection in this group of patients. We herein provide a comprehensive and up-to-date overview of the role of

Indexed as

ACE-2CoronavirusCOVID-19inhibitorslung cancerSARS-CoV-2TMPRSS2

Identifiers

PMID32764454
PMCPMC7464614
OpenAlexW3047119181

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.