Evidence map›Paper›PMID 32764436›Full record

ArticleDiagnostics (Basel, Switzerland)2020

aMMP-8 Point-of-Care/Chairside Oral Fluid Technology as a Rapid, Non-Invasive Tool for Periodontitis and Peri-Implantitis Screening in a Medical Care Setting.

Hanna Lähteenmäki, Kehinde A Umeizudike, Anna Maria Heikkinen, Ismo T Räisänen, Nilminie Rathnayake, Gunnar Johannsen, Taina Tervahartiala, Solomon O Nwhator, Timo Sorsa

2 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06408467 nacompletednot on this mapstarted 2022, after this paper: background citation

Monitoring of Non-Surgical Treatment of Peri-implantitis, Traditional Measurement Methods and aMMP-8 Test Technology-Cross Sectional Study

TypeinterventionalSponsorLahanna oyRan2022 to 2022Enrolled40ConditionsPeri-implant Mucositis, Peri-ImplantitisArmsaMMP-8 diagnostic test
NCT06761521 naenrolling by invitationnot on this mapstarted 2025, after this paper: background citation

Monitoring of Implant Diseases: Diagnosis and Monitoring With aMMP-8 Test Technology: A 5-year Follow-up Study

TypeinterventionalSponsorHanna LahteenmakiRan2025 to 2025Enrolled50ConditionsPeri-Implant Health, Peri-Implantitis and Peri-implant MucositisArmsPeri-Implantitis and Peri-implant mucositis
3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 53 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Hanna LähteenmäkiDepartment of Oral and Maxillofacial Diseases, Head and Neck Center, University of Helsinki and Helsinki University Hospital, PO Box 63 (Haartmaninkatu 8), FI-00014 Helsinki, Finland.ORCID 0000-0002-7914-9726
Kehinde A UmeizudikeDepartment of Preventive Dentistry, Faculty of Dental Sciences, College of Medicine, University of Lagos, Lagos 100213, Nigeria.ORCID 0000-0003-4893-872X
Anna Maria HeikkinenDepartment of Oral and Maxillofacial Diseases, Head and Neck Center, University of Helsinki and Helsinki University Hospital, PO Box 63 (Haartmaninkatu 8), FI-00014 Helsinki, Finland.
Ismo T RäisänenDepartment of Oral and Maxillofacial Diseases, Head and Neck Center, University of Helsinki and Helsinki University Hospital, PO Box 63 (Haartmaninkatu 8), FI-00014 Helsinki, Finland.ORCID 0000-0001-5821-5299
Nilminie RathnayakeDepartment of Oral and Maxillofacial Diseases, Head and Neck Center, University of Helsinki and Helsinki University Hospital, PO Box 63 (Haartmaninkatu 8), FI-00014 Helsinki, Finland.ORCID 0000-0002-1914-5934
Gunnar JohannsenDivision of Periodontology, Department of Dental Medicine, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
Taina TervahartialaDepartment of Oral and Maxillofacial Diseases, Head and Neck Center, University of Helsinki and Helsinki University Hospital, PO Box 63 (Haartmaninkatu 8), FI-00014 Helsinki, Finland.ORCID 0000-0001-8817-896X
Solomon O NwhatorDepartment of Preventive & Community Dentistry, Faculty of Dentistry, College of Health Sciences, Obafemi Awolowo University, Ile-Ife A234, Nigeria.ORCID 0000-0003-3161-8092
Timo SorsaDepartment of Oral and Maxillofacial Diseases, Head and Neck Center, University of Helsinki and Helsinki University Hospital, PO Box 63 (Haartmaninkatu 8), FI-00014 Helsinki, Finland.
University of Helsinki · FIKarolinska Institutet · SEObafemi Awolowo University · NGUniversity of Lagos · NG

Funding

Helsingin Yliopiston Tiedesäätiö TYH2016251Helsingin Yliopiston Tiedesäätiö TYH2017251Helsingin Yliopiston Tiedesäätiö TYH2018229Helsingin Yliopiston Tiedesäätiö TYH2019319Helsingin Yliopiston Tiedesäätiö Y1014SL017Helsingin Yliopiston Tiedesäätiö Y1014SL018Helsingin Yliopiston Tiedesäätiö Y1014SULE1Karolinska Institutet N/A
6 · The paper itself

Abstract

This communication article addresses currently available rapid non-invasive methods to screen and detect periodontitis and dental peri-implantitis. In this regard, oral fluid biomarkers have been researched extensively but self-reported oral health (SROH)-questionnaires have also been developed. Both alternatives may offer a quick and easy way to screen and detect diseased patients. Active matrix metalloproteinase (aMMP-8) is one of the most validated biomarkers for screening and detecting periodontal breakdown related to periodontitis and peri-implantitis and monitoring their treatment effects revealing successful, less- and non-successful treatment results. Currently available aMMP-8 lateral-flow technologies allow this kind of analysis, as demonstrated here, to be conducted quantitatively online and real-time as point-of-care/chairside testing in dental and even medical care settings. In this study, an aMMP-8 peri-implant sulcular fluid point-of-care-test diagnosed peri-implantitis and healthy implants far more accurately than bleeding-on-probing or the other biomarkers, such as polymorphonuclear (PMN)/neutrophil elastase, myeloperoxidase and MMP-9. Although, SROH-questionnaires allow screening in similar settings but they lack the information about the current disease activity of periodontitis and peri-implantitis, which is of essential value in periodontal diagnostics and treatment monitoring. Thus, both methods can be considered as adjunct methods for periodontitis and peri-implant diagnostics, but the value of oral fluid biomarkers analysis does not seem to be substitutable.

Indexed as

aMMP-8biomarkersbiosensorsperi-implantitisperiodontitispoint-of-care diagnosticspoint-of-care testingscreening

Identifiers

PMID32764436
PMCPMC7460514
OpenAlexW3046963114

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.