Inclusion Formation and Toxicity of the ALS Protein RGNEF and Its Association with the Microtubule Network.

Sonja E Di Gregorio, Kathryn Volkening, Michael J Strong, Martin L Duennwald

Open access · goldAbstract read

In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it

0cells of the map it votes in

5citing papers in PubMed

0.8field-weighted citation impact, top 23% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

Saccharomyces cerevisiae as a research tool for RNA-mediated human disease.Wiley interdisciplinary reviews. RNA · 2023
Review
Astroglial Hmgb1 regulates postnatal astrocyte morphogenesis and cerebrovascular maturation.Nature communications · 2023
Article
Dysregulated miRNAs as Biomarkers and Therapeutical Targets in Neurodegenerative Diseases.Journal of personalized medicine · 2022
Review
Utility of RGNEF in the Prediction of Clinical Prognosis in Patients with Rectal Cancer Receiving Preoperative Concurrent Chemoradiotherapy.Life (Basel, Switzerland) · 2021
Article
A Quantitative Imaging-Based Protocol for Yeast Growth and Survival on Agar Plates.STAR protocols · 2020
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sonja E Di GregorioDepartment of Pathology and Laboratory Medicine, University of Western Ontario, London, ON N6A 5C1, Canada.

Kathryn VolkeningClinical Neurological Sciences, University of Western Ontario, London, ON N6A 5C1, Canada.ORCID 0000-0002-7601-4869

Michael J StrongClinical Neurological Sciences, University of Western Ontario, London, ON N6A 5C1, Canada.

Martin L DuennwaldDepartment of Pathology and Laboratory Medicine, University of Western Ontario, London, ON N6A 5C1, Canada.

Western University · CA

Funding

ALS Society of Canada Bernice Ramsey, Trainee Scholarship

6 · The paper itself

Abstract

The Rho guanine nucleotide exchange factor (RGNEF) protein encoded by the

Indexed as

Amyotrophic Lateral SclerosisAnimalsGene Expression RegulationGuanine Nucleotide Exchange FactorsHeterozygoteHumansMammalsMicrotubulesMutationNeuronsProtein BindingUbiquitinYeastsARHGEF28 protein, humanGuanine Nucleotide Exchange FactorsUbiquitinALSmicrotubulesneurodegenerationprotein misfoldingRGNEFyeast model

Identifiers

PMID32764283

DOI10.3390/ijms21165597

PMCPMC7460592

OpenAlexW3041310689

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.