Evidence map›Paper›PMID 32764136›Full record

ArticleJournal of the American Society of Nephrology : JASN2020

Mechanisms Regulating Muscle Protein Synthesis in CKD.

Liping Zhang, Qin Chen, Zihong Chen, Ying Wang, Jorge L Gamboa, Talat Alp Ikizler, Giacomo Garibotto, William E Mitch

Erratum issuedOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 27 citations in OpenAlex.

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  16. A New Dimension to the Mechanisms Causing Muscle Loss in CKD.Journal of the American Society of Nephrology : JASN · 2020
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Liping ZhangNephrology Division, Department of Medicine, Baylor College of Medicine, Houston, Texas lipingz@bcm.edu.
Qin ChenDepartment of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Zihong ChenNephrology Division, Department of Medicine, Baylor College of Medicine, Houston, Texas.
Ying WangNephrology Division, Department of Medicine, Baylor College of Medicine, Houston, Texas.
Jorge L GamboaDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Talat Alp IkizlerDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.ORCID 0000-0002-5717-4218
Giacomo GaribottoNephrology Division, Department of Internal Medicine, Genoa University, Scientific Hospitalization and Treatment Institute Policlinico San Martino Hospital, Genoa, Italy.ORCID 0000-0001-6432-2429
William E MitchNephrology Division, Department of Medicine, Baylor College of Medicine, Houston, Texas.
Baylor College of Medicine · USVanderbilt University Medical Center · USOspedale Policlinico San Martino · ITThe University of Texas MD Anderson Cancer Center · US

Funding

Diabetes Endocrinology Research CenterP30DK079638 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI CHAN, LAWRENCE · 2008 to 2012
$6.4M
PROTEIN NUTRITION IN EXPERIMENTAL UREMIAR01DK037175 · NIDDK · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI Zhaoyong Hu · 1986 to 2026
$4.3M
Mechanisms underlying atrial fibrillation associated with chronic kidney diseaseR01HL147108 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI LI, NA, WEHRENS, XANDER H.T. · 2019 to 2022
$2.0M
NHLBI NIH HHS R01 HL147108NIDDK NIH HHS P30 DK079638NIDDK NIH HHS R01 DK037175
6 · The paper itself

Abstract

backgroundCKD induces loss of muscle proteins partly by suppressing muscle protein synthesis. Muscles of mice with CKD have increased expression of nucleolar protein 66 (NO66), as do muscle biopsy specimens from patients with CKD or those undergoing hemodialysis. Inflammation stimulates NO66 expression and changes in NF-

methodsSubtotal nephrectomy created a mouse model of CKD with BUN >80 mg/dl. Crossing NO66

resultsMuscle-specific NO66 knockout in mice blocks CKD-induced loss of muscle mass and improves protein synthesis. NO66 suppression of ribosomal biogenesis

conclusionsCKD suppresses muscle protein synthesis

Indexed as

AdultAgedAnimalsCell LineDioxygenasesDisease Models, AnimalDNA, RibosomalEpigenesis, GeneticFemaleGene ExpressionHistone DemethylasesHistonesHumansInterferon-gammaInterleukin-6Jumonji Domain-Containing Histone DemethylasesDioxygenasesDNA, RibosomalFBXO32 protein, humanHistone Demethylaseshistone H3 trimethyl Lys4HistonesIL6 protein, humanInterferon-gammaInterleukin-6Jumonji Domain-Containing Histone DemethylasesMuscle ProteinsNF-kappa Bnucleolar protein 66, mouseRIOX1 protein, humanRNA, MessengerSKP Cullin F-Box Protein LigasesTRIM63 protein, humanTripartite Motif ProteinsTumor Necrosis Factor-alphaUbiquitin-Protein Ligaseschronic kidney diseaseepigeneticsmuscle wastingprotein metabolismprotein synthesisribosomal RNA transcription

Identifiers

PMID32764136
PMCPMC7608956
OpenAlexW3048239813

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.