Evidence map›Paper›PMID 32764120›Full record

ReviewJournal of nuclear medicine : official publication, Society of Nuclear Medicine2020

Nuclear Imaging of Bacterial Infection: The State of the Art and Future Directions.

Ilona Polvoy, Robert R Flavell, Oren S Rosenberg, Michael A Ohliger, David M Wilson

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
9.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 79 citations in OpenAlex.

  1. Article
  2. Article
  3. Discovery of a Thermostable Nigerose Phosphorylase for the Efficient Chemoenzymatic Radiosynthesis of aJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Positron Emission Tomography Imaging ofACS infectious diseases · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. ACS infectious diseases · 2025
    Article
  15. d-[5-ACS infectious diseases · 2025
    Article
  16. Article
  17. Quantitative in Vivo Molecular MRI.Advanced materials (Deerfield Beach, Fla.) · 2024
    Review
  18. Review
  19. Biological Evaluation of d-[Journal of medicinal chemistry · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ilona PolvoyDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California.
Robert R FlavellDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California.
Oren S RosenbergDepartment of Medicine, University of California, San Francisco, San Francisco, California; and.
Michael A OhligerDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California.
David M WilsonDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California david.m.wilson@ucsf.edu.
University of California, San Francisco · USSan Francisco General Hospital · US

Funding

Development of 11C-PABA as a bacteria-specific imaging agent for spinal infectionsR01EB025985 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JAIN, SANJAY, WILSON, DAVID M · 2018 to 2021
$2.7M
Clinical translation of D-amino acid derived PET tracers for imaging spinalinfectionR01EB024014 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI OHLIGER, MICHAEL, WILSON, DAVID M · 2017 to 2020
$2.2M
NIBIB NIH HHS R01 EB024014NIBIB NIH HHS R01 EB025985
6 · The paper itself

Abstract

Increased mortality rates from infectious diseases is a growing public health concern. Successful management of acute bacterial infections requires early diagnosis and treatment, which are not always easy to achieve. Structural imaging techniques such as CT and MRI are often applied to this problem. However, these methods generally rely on secondary inflammatory changes and are frequently not specific to infection. The use of nuclear medicine techniques can add crucial complementary information, allowing visualization of infectious pathophysiology beyond morphologic imaging. This review will discuss the current structural and functional imaging techniques used for the diagnosis of bacterial infection and their roles in different clinical scenarios. We will also present several new radiotracers in development, with an emphasis on probes targeting bacteria-specific metabolism. As highlighted by the current coronavirus disease 2019 epidemic, caused by the novel severe acute respiratory syndrome coronavirus 2, similar thinking may apply in imaging viral pathogens; for this case, prominent effects on host proteins, most notably angiotensin-converting enzyme 2, might also provide worthwhile imaging targets.

Indexed as

AnimalsBacterial InfectionsDiagnostic ImagingHumansNuclear Medicineimaginginfectionnuclear medicinePETSPECT

Identifiers

PMID32764120
PMCPMC9364899
OpenAlexW3048307368

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.