Evidence map›Paper›PMID 32763975›Full record

ArticleThe Journal of biological chemistry2020

Acetylation modulates the Fanconi anemia pathway by protecting FAAP20 from ubiquitin-mediated proteasomal degradation.

Bhavika Nagareddy, Arafat Khan, Hyungjin Kim

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Bhavika NagareddyDepartment of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook, New York, USA.
Arafat KhanDepartment of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook, New York, USA.
Hyungjin KimDepartment of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook, New York, USA; Stony Brook Cancer Center, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York, USA. Electronic address: hyungjin.kim@stonybrook.edu.
State University of New York · US

Funding

Proteolytic control of DNA interstrand cross-link repair and genome integrityR01CA218132 · NCI · STATE UNIVERSITY NEW YORK STONY BROOK · PI KIM, HYUNGJIN · 2018 to 2022
$1.8M
NCI NIH HHS R01 CA218132
6 · The paper itself

Abstract

Fanconi anemia (FA) is a chromosome instability syndrome of children caused by inherited mutations in one of FA genes, which together constitute a DNA interstrand cross-link (ICL) repair, or the FA pathway. Monoubiquitination of Fanconi anemia group D2 protein (FANCD2) by the multisubunit ubiquitin E3 ligase, the FA core complex, is an obligate step in activation of the FA pathway, and its activity needs to be tightly regulated. FAAP20 is a key structural component of the FA core complex, and regulated proteolysis of FAAP20 mediated by prolyl

Indexed as

ProteolysisUbiquitinationAcetylationCell Line, TumorFanconi Anemia Complementation Group D2 ProteinFanconi Anemia Complementation Group ProteinsHumansProteasome Endopeptidase ComplexUbiquitinFAAP20 protein, humanFANCD2 protein, humanFanconi Anemia Complementation Group D2 ProteinFanconi Anemia Complementation Group ProteinsProteasome Endopeptidase ComplexUbiquitinacetylationacetyltransferaseDNA repairFanconi anemiagenome stabilitylysine acetylationpost-translational modification (PTM)protein stabilityproteolysisthe FA core complexubiquitylation (ubiquitination)

Identifiers

PMID32763975
PMCPMC7535921
OpenAlexW3047990754

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.