ArticleOpen heart2020
Value of FEops HEARTguide patient-specific computational simulations in the planning of left atrial appendage closure with the Amplatzer Amulet closure device: rationale and design of the PREDICT-LAA study.
Article in Open heart, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04180605 (The Value of FEops HEARTguideTM Patient-Specific Computational Simulation in the Planning of Percutaneous Left Atrial Appendage Closure With the AmplatzerTM AmuletTM Device), which is not on this map. Cited by 19 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Value of FEops HEARTguideTM Patient-Specific Computational Simulation in the Planning of Percutaneous Left Atrial Appendage Closure With the AmplatzerTM AmuletTM Device (PREDICT-LAA)
Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- AI-powered in silico twins: redefining precision medicine through simulation, personalization, and predictive healthcare.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2025Review
- Advanced Computer Simulation Based on Cardiac Imaging in Planning of Structural Heart Disease Interventions.Journal of clinical medicine · 2025Review
- Functional Mitral Regurgitation in the Transcatheter Era: Diagnostic and Therapeutic Pathways.Journal of personalized medicine · 2025Review
- Percutaneous Left Atrial Appendage Closure: Supporting Evidence, Limitations and Future Directions.Journal of clinical medicine · 2025Review
- Measure twice, implant once.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2024Article
- Evolutionary trends and innovations in cardiovascular intervention.Frontiers in medical technology · 2024Article
- 'Just the two of us': single-operator interventional left atrial appendage closure-a case report.European heart journal. Case reports · 2023Article
- Left atrial appendage occlusion.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2023Review
- Domain expert evaluation of advanced visual computing solutions and 3D printing for the planning of the left atrial appendage occluder interventions.International journal of bioprinting · 2023Article
- The Art of Planning a Left Atrial Appendage Closure: Will Computational Modeling Simplify the Intervention?JACC. Advances · 2022Article
- Left Atrial Appendage Occlusion: Current Advances and Remaining Challenges.JACC. Advances · 2022Review
- Not to Rush-Laboratory Parameters and Procedural Complications in Patients Undergoing Left Atrial Appendage Closure.Journal of clinical medicine · 2022Article
- Use of FEops artificial intelligence enabled technology for preprocedural planning of left atrial appendage occlusion with Amulet Amplatzer device.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2022Article
- Percutaneous closure of a 'whale tail' left atrial appendage with a Watchman FLX device and pre-procedural FEops HEARTguide patient-specific computational simulation: a case report.European heart journal. Case reports · 2022Article
- The year in cardiovascular medicine 2021: interventional cardiology.European heart journal · 2022Article
- Review
- Clinical Impact of Preprocedural CT-Based 3D Computational Simulation of Left Atrial Appendage Occlusion with Amulet.Journal of interventional cardiology · 2021Article
- Left atrial appendage occlusion in COVID-19 times.European heart journal supplements : journal of the European Society of Cardiology · 2020Article
- Left Atrial Appendage Occlusion: Current Stroke Prevention Strategies and a Shift Toward Data-Driven, Patient-Specific Approaches.Journal of the Society for Cardiovascular Angiography & InterventionsReview
Corrections and comments
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Authors and funding
15 authors at 13 institutions in 8 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOptimal preprocedural planning is essential to ensure successful device closure of the left atrial appendage (LAA).
designThe PREDICT-LAA study is a prospective, international, multicentre, randomised controlled trial (ClinicalTrials.gov NCT04180605). Two hundred patients eligible for LAA closure with an Amplatzer Amulet device (Abbott, USA) will be enrolled in the study. Patients will be allocated to a computational simulation arm (experimental) or standard treatment arm (control) using a 1:1 randomisation. For patients randomised to the computational simulation arm, preprocedural planning will be based on the analysis of cardiac computed tomography (CCT)-based patient-specific computational simulations (FEops HEARTguide, Ghent, Belgium) in order to predict optimal device size and position. For patients in the control arm, preprocedural planning will be based on local practice including CCT analysis. The LAA closure procedure and postprocedural antithrombotic therapy will follow local practice in both arms. The primary endpoint of the study is incomplete LAA closure and device-related thrombus as assessed at 3 months postprocedural CCT. Secondary endpoints encompass procedural efficiency (number of devices used, number of repositioning, procedural time, radiation exposure, contrast dye), procedure-related complications within 7 days postprocedure and a composite of all-cause death and thromboembolic events at 12 months.
conclusionThe objective of the PREDICT-LAA study is to test the hypothesis that a preprocedural planning for LAA closure with the Amplatzer Amulet device based on patient-specific computational simulations can result in a more efficient procedure, optimised procedural outcomes and better clinical outcomes as compared with a standard preprocedural planning. TRIAL REGISTRATION NUMBER: ClinicalTrials.gov Registry (NCT04180605).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.