Evidence map›Paper›PMID 32763910›Full record

ArticleGenes & development2020

miR760 regulates ATXN1 levels via interaction with its 5' untranslated region.

Larissa Nitschke, Ambika Tewari, Stephanie L Coffin, Eder Xhako, Kaifang Pang, Vincenzo A Gennarino, Jennifer L Johnson, Francisco A Blanco, Zhandong Liu, Huda Y Zoghbi

Open access · diamondAbstract read
In one paragraph

Article in Genes & development, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
  2. Review
  3. Discovery of NovelGenes · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Epigenetic control of ataxin-1 in multiple sclerosis.Annals of clinical and translational neurology · 2022
    Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Larissa NitschkeProgram in Integrative Molecular and Biomedical Sciences, Baylor College of Medicine, Houston, Texas 77030, USA.
Ambika TewariDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
Stephanie L CoffinDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
Eder XhakoDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
Kaifang PangJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, Texas 77030, USA.
Vincenzo A GennarinoDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
Jennifer L JohnsonDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
Francisco A BlancoProgram in Integrative Molecular and Biomedical Sciences, Baylor College of Medicine, Houston, Texas 77030, USA.
Zhandong LiuJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, Texas 77030, USA.
Huda Y ZoghbiProgram in Integrative Molecular and Biomedical Sciences, Baylor College of Medicine, Houston, Texas 77030, USA.
Baylor College of Medicine · USNeurological Research Institute · USTexas Children's Hospital · US

Funding

Preclinical and Clincial OutcomesP50HD103555 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI Sandesh Chakravarthy Sreenath Nagamani, David Loren Nelson · 2020 to 2026
$9.9M
Steps towards a paternal gene activation therapy for Angelman syndromeU54HD083092 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI NELSON, DAVID LOREN, NEUL, JEFFREY L · 2014 to 2019
$7.8M
MOLECULAR STUDIES OF SPINOCEREBELLAR ATAXIS TYPE IR37NS027699 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI ZOGHBI, HUDA Y · 2015 to 2021
$2.8M
Howard Hughes Medical InstituteNICHD NIH HHS P50 HD103555NICHD NIH HHS U54 HD083092NINDS NIH HHS R37 NS027699
6 · The paper itself

Abstract

Identifying modifiers of dosage-sensitive genes involved in neurodegenerative disorders is imperative to discover novel genetic risk factors and potential therapeutic entry points. In this study, we focus on Ataxin-1 (

Indexed as

5' Untranslated RegionsAnimalsAtaxin-1Cell LineGene Expression RegulationHumansMiceMice, Inbred C57BLMicroRNAsMutationRisk FactorsSpinocerebellar Ataxias5' Untranslated RegionsAtaxin-1MicroRNAsMIRN760 microRNA, human5′ UTRmiRNAneurodegenerationSCA1

Identifiers

PMID32763910
PMCPMC7462065
OpenAlexW3047935254

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.