ArticleCurrent biology : CB2020
A Molecular Signal Integration Network Underpinning Arabidopsis Seed Germination.
Article in Current biology : CB, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
44 citing papers in PubMed, 94 citations in OpenAlex.
- Seed-specific overexpression of DREB2G alters seed morphology, oil accumulation, and germination in Arabidopsis.Plant cell reports · 2026Article
- The transcriptional dynamics of TIFY/JAZ and BBX families in jasmonate signaling reveal SlBBX17 as a positive regulator of tomato defense.Plant cell reports · 2026Article
- Holistic overview of regulatory networks governing seed dormancy and germination in plants.Science China. Life sciences · 2026Review
- ABT Promotes Adventitious Root Formation in Mulberry Cuttings by Coordinating Hormonal Homeostasis and Defense Priming.Current issues in molecular biology · 2026Article
- Natural variation in Phosphatidylinositol 4-Kinase OsPI4Kγ7 and its interaction with OsLIC balance rice yield and latitudinal adaptation.Nature communications · 2026Article
- Integrated Transcriptomic and Biochemical Analyses Reveal the Root Development-Promoting Mechanism ofPlants (Basel, Switzerland) · 2025Article
- OsGSTT3 regulates seed germination by modulating reactive oxygen species homeostasis in rice.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Fumarylacetoacetate Hydrolase Regulates Seed Dormancy and Germination Through the Gibberellin Pathway in Arabidopsis.Plants (Basel, Switzerland) · 2025Article
- DSK2-mediated degradation of F-box protein LAO1 and class I TCPs modulates the nitrogen starvation response.EMBO reports · 2025Article
- Transcription factor ERF1 promotes seed germination by repressing jasmonic acid (JA) signaling pathway.Plant cell reports · 2025Article
- A DOF transcriptional repressor-gibberellin feedback loop plays a crucial role in modulating light-independent seed germination.Plant communications · 2025Article
- Overexpression ofInternational journal of molecular sciences · 2025Article
- Epitranscriptome profiles reveal participation of the RNA methyltransferase gene OsMTA1 in rice seed germination and salt stress response.BMC plant biology · 2025Article
- Establishment of single-cell transcriptional states during seed germination.Nature plants · 2024Article
- A commitment for life: Decades of unraveling the molecular mechanisms behind seed dormancy and germination.The Plant cell · 2024Review
- Comparative regulatory network of transcripts behind radicle emergence and seedling stage of maize (Heliyon · 2024Article
- Integrated Metabolome and Transcriptome Analysis of Gibberellins Mediated the Circadian Rhythm of Leaf Elongation by Regulating Lignin Synthesis in Maize.International journal of molecular sciences · 2024Article
- Plant growth regulators mitigate oxidative damage to rice seedling roots by NaCl stress.PeerJ · 2024Article
- Integrated Transcriptome and Proteome Analysis Revealed the Regulatory Mechanism of Hypocotyl Elongation in Pakchoi.International journal of molecular sciences · 2023Article
- Genome-Wide Analysis of TCP Transcription Factors and Their Expression Pattern Analysis of Rose Plants (Current issues in molecular biology · 2023Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
Seed dormancy is an adaptive trait defining where and when plants are established. Diverse signals from the environment are used to decide when to initiate seed germination, a process driven by the expansion of cells within the embryo. How these signals are integrated and transduced into the biomechanical changes that drive embryo growth remains poorly understood. Using Arabidopsis seeds, we demonstrate that cell-wall-loosening EXPANSIN (EXPA) genes promote gibberellic acid (GA)-mediated germination, identifying EXPAs as downstream molecular targets of this developmental phase transition. Molecular interaction screening identified transcription factors (TFs) that bind to both EXPA promoter fragments and DELLA GA-response regulators. A subset of these TFs is targeted each by nitric oxide (NO) and the phytochrome-interacting TF PIL5. This molecular interaction network therefore directly links the perception of an external environmental signal (light) and internal hormonal signals (GA and NO) with downstream germination-driving EXPA gene expression. Experimental validation of this network established that many of these TFs mediate GA-regulated germination, including TCP14/15, RAP2.2/2.3/2.12, and ZML1. The reduced germination phenotype of the tcp14 tcp15 mutant seed was partially rescued through ectopic expression of their direct target EXPA9. The GA-mediated control of germination by TCP14/15 is regulated through EXPA-mediated control of cell wall loosening, providing a mechanistic explanation for this phenotype and a previously undescribed role for TCPs in the control of cell expansion. This network reveals the paths of signal integration that culminate in seed germination and provides a resource to uncover links between the genetic and biomechanical bases of plant growth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.