Evidence map›Paper›PMID 32763157›Full record

ArticleStem cell reports2020

MiR-126 Regulates Properties of SOX9

Yi Yan, Rui Wang, Xiongji Hu, Shichao Wang, Liang Zhang, Chenjiao Hou, Lisheng Zhang

Open access · goldAbstract read
In one paragraph

Article in Stem cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
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  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Bellidifolin Inhibits SRY-Related High Mobility Group-Box Gene 9 to Block TGF-Evidence-based complementary and alternative medicine : eCAM · 2022
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yi YanCollege of Veterinary Medicine, Bio-medical Center, Huazhong Agricultural University, Wuhan, Hubei 430070, China.
Rui WangCollege of Veterinary Medicine, Bio-medical Center, Huazhong Agricultural University, Wuhan, Hubei 430070, China.
Xiongji HuCollege of Veterinary Medicine, Bio-medical Center, Huazhong Agricultural University, Wuhan, Hubei 430070, China.
Shichao WangCollege of Veterinary Medicine, Bio-medical Center, Huazhong Agricultural University, Wuhan, Hubei 430070, China.
Liang ZhangCollege of Veterinary Medicine, Bio-medical Center, Huazhong Agricultural University, Wuhan, Hubei 430070, China.
Chenjiao HouCollege of Veterinary Medicine, Bio-medical Center, Huazhong Agricultural University, Wuhan, Hubei 430070, China.
Lisheng ZhangCollege of Veterinary Medicine, Bio-medical Center, Huazhong Agricultural University, Wuhan, Hubei 430070, China. Electronic address: lishengzhang@mail.hzau.edu.cn.
Huazhong Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liver progenitor cells (LPCs) have a remarkable contribution to the hepatocytes and ductal cells when normal hepatocyte proliferation is severely impaired. As a biomarker for LPCs, Sry-box 9 (Sox9) plays critical roles in liver homeostasis and repair in response to injury. However, the regulation mechanism of Sox9 in liver physiological and pathological state remains unknown. In this study, we found that miR-126 positively regulated the expression of Sox9, the proliferation and differentiation of SOX9

Indexed as

Liver RegenerationAnimalsBase SequenceCarbon TetrachlorideCell DifferentiationCell Line, TumorCell ProliferationChronic DiseaseDependovirusDisease Models, AnimalHepatocytesHomeodomain ProteinsLiverMaleMiceMice, Inbred C57BLCarbon TetrachlorideHomeodomain ProteinsHoxb6 protein, mouseMicroRNAsMIRN126 microRNA, mouseSOX9 Transcription Factordifferentiationinjury repairliver stem cellsMiR-126proliferation

Identifiers

PMID32763157
PMCPMC7486193
OpenAlexW3047328163

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.