ReviewTrends in neurosciences2020
Hypothalamic Interactions with Large-Scale Neural Circuits Underlying Reinforcement Learning and Motivated Behavior.
Review in Trends in neurosciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- A synaptic mechanism for encoding the learned value of action-derived safety.Nature communications · 2026Article
- Spatiotemporal Decoding of Explore-Exploit Decisions in the Human Brain.bioRxiv : the preprint server for biology · 2026Article
- Early-Age Cuprizone Exposure Induces Region-Specific Demyelination and Neuroinflammation in Mice.Neuromolecular medicine · 2026Article
- Frustration brake failure hypothesis of substance use disorders.Frontiers in psychiatry · 2026Article
- Sexual dimorphism and acute stress modulation of infralimbic-posterior hypothalamic synaptic transmission.Frontiers in cellular neuroscience · 2026Article
- Principal axis of primate basal ganglia in processing cognitive flexibility and habitual stability.Brain : a journal of neurology · 2025Review
- Transcriptomic diversity of amygdalar subdivisions across humans and nonhuman primates.Science advances · 2025Article
- Digit Span Tests Are More Sensitive than SDMT for Detecting Working Memory Impairment and Correlate with Metabolic Alterations in White Matter and Deep Gray Matter Nuclei in Multiple Sclerosis: A GABA-Edited Magnetic Resonance Spectroscopy Study.International journal of molecular sciences · 2025Article
- The interoceptive origin of reinforcement learning.Trends in cognitive sciences · 2025Review
- Neuropeptidergic transmission shapes emergent properties of prefrontal cortical circuits underlying learning.bioRxiv : the preprint server for biology · 2025Article
- Developmental changes in brain-wide fear memory networks.Neurobiology of learning and memory · 2025Article
- Dorsal-Ventral Reinforcement Learning Network Connectivity and Incentive-Driven Changes in Exploration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Hypothalamic resting-state functional connectivity and self-evaluated aggression in young adults.Journal of psychiatric research · 2025Article
- Applications of Behavioral Economics and Neuroeconomics in Mental Health.Iranian journal of psychiatry · 2025Review
- The Organization of Anxiety Symptoms Along the Threat Imminence Continuum.Current topics in behavioral neurosciences · 2025Review
- The cost of language: functionally over-dominant language circuits in the human brain may limit cognitive abilities and non-verbal executive functions.Frontiers in human neuroscience · 2025Article
- PM2.5 Exposure Triggers Hypothalamic Oxidative and ER Stress Leading to Depressive-like Behaviors in Rats.International journal of molecular sciences · 2024Article
- Modeling long-term nutritional behaviors using deep homeostatic reinforcement learning.PNAS nexus · 2024Article
- Ventral frontostriatal circuitry mediates the computation of reinforcement from symbolic gains and losses.Neuron · 2024Article
- Hypothalamic connectivities and self-evaluated aggression in young adults.bioRxiv : the preprint server for biology · 2024Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Biological agents adapt behavior to support the survival needs of the individual and the species. In this review we outline the anatomical, physiological, and computational processes that support reinforcement learning (RL). We describe two circuits in the primate brain that are linked to specific aspects of learning and goal-directed behavior. The ventral circuit, that includes the amygdala, ventral medial prefrontal cortex, and ventral striatum, has substantial connectivity with the hypothalamus. The dorsal circuit, that includes inferior parietal cortex, dorsal lateral prefrontal cortex, and the dorsal striatum, has minimal connectivity with the hypothalamus. The hypothalamic connectivity suggests distinct roles for these circuits. We propose that the ventral circuit defines behavioral goals, and the dorsal circuit orchestrates behavior to achieve those goals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.