ArticleJournal of the American College of Cardiology2020
Validation of a Genome-Wide Polygenic Score for Coronary Artery Disease in South Asians.
Open access · greenAbstract readValidation Study
In one paragraph
Article in Journal of the American College of Cardiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
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68citing papers in PubMed, 1 pooled it
13.1field-weighted citation impact, top 1% of its field
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Who cites it
68 citing papers in PubMed, 1 synthesis or guideline pooled it, 109 citations in OpenAlex.
- Polygenic Risk Score and Statin Relative Risk Reduction for Primary Prevention of Myocardial Infarction in a Real-World Population.Clinical pharmacology and therapeutics · 2022 · on this mapPooled it
- South Asian Cardiovascular Risk: Role of Coronary Artery Calcium Scoring and Computed Tomography Angiography.JACC. Asia · 2026Review
- Inherited risk of coronary artery disease: redefining care with imaging and genetics.Nature reviews. Cardiology · 2026Review
- Drivers of Atherosclerotic Cardiovascular Disease in South Asians: Current Insights and Future Directions.JACC. Asia · 2026Review
- Validated Polygenic Risk Scores Complement Monogenic Testing in South Asian Patients With Familial Hypercholesterolemia.JACC. Asia · 2026Article
- DiscoDivas: Leveraging genetic-ancestry continuum information to interpolate PRS for admixed populations.American journal of human genetics · 2026Article
- Are polygenic scores for psychiatric and substance use outcomes "ready" for clinical application? Current state and next steps.Psychiatric genetics · 2026Review
- Admixture-informed polygenic risk reporting using the ePRS framework.Nature communications · 2026Article
- Genetic and Conventional Risk Stratification Are Complementary for Primary Prevention of CAD.Methodist DeBakey cardiovascular journal · 2026Review
- Real-time dynamic polygenic prediction for streaming data.Nature genetics · 2025Article
- DiscoDivas: Leveraging genetic ancestry continuum information to interpolate PRS for admixed populations.medRxiv : the preprint server for health sciences · 2025Article
- Cancer, genetic susceptibility and risk of coronary artery disease: A prospective study.American journal of preventive cardiology · 2025Article
- 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2025Review
- Validation of a genome-wide polygenic score for body mass index in South Asians.Frontiers in genetics · 2025Article
- Genetic Risk Score Enables a Vaccine for Early Primary Prevention of CAD.Methodist DeBakey cardiovascular journal · 2025Review
- The expected polygenic risk score (ePRS) framework: an equitable metric for quantifying polygenetic risk via modeling of ancestral makeup.medRxiv : the preprint server for health sciences · 2024Article
- Polygenic Risk Score Assessment for Coronary Artery Disease in Asian Indians.Journal of cardiovascular translational research · 2024Article
- Genetic Polymorphisms and Genetic Risk Scores Contribute to the Risk of Coronary Artery Disease (CAD) in a North Indian Population.International journal of molecular sciences · 2024Article
- Polygenic risk and incident coronary heart disease in a large multiethnic cohort.American journal of preventive cardiology · 2024Article
- Multi-Ancestry Polygenic Risk Score for Coronary Heart Disease Based on an Ancestrally Diverse Genome-Wide Association Study and Population-Specific Optimization.Circulation. Genomic and precision medicine · 2024Article
8 more citing papers are in PubMed but not listed here.
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Authors and funding
36 authors at 12 institutions in 5 countries.
Minxian WangCardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts.
Ramesh MenonMedGenome Labs Ltd., Bengaluru, India.
Sanghamitra MishraMedGenome Labs Ltd., Bengaluru, India.
Aniruddh P PatelCardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts; Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts; Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts.
Mark ChaffinCardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts.
Deepak TanneeruMedGenome Labs Ltd., Bengaluru, India.
Manjari DeshmukhMedGenome Labs Ltd., Bengaluru, India.
Oshin MathewMedGenome Labs Ltd., Bengaluru, India.
Sanika ApteMedGenome Labs Ltd., Bengaluru, India.
Christina S DevanbooMedGenome Labs Ltd., Bengaluru, India.
Sumathi SundaramMedGenome Labs Ltd., Bengaluru, India.
Praveena LakshmipathyMedGenome Labs Ltd., Bengaluru, India.
Sakthivel MuruganMedGenome Labs Ltd., Bengaluru, India.
Krishna Kumar SharmaEternal Heart Care Centre, Jaipur, India.
Karthikeyan RajendranNarayana Health, Bengaluru, India.
Sam SanthoshMedGenome Labs Ltd., Bengaluru, India.
Rajesh ThachathodiylAmrita Institute Medical Sciences, Kochi, India.
Hisham AhamedAmrita Institute Medical Sciences, Kochi, India.
Aniketh Vijay BalegaddeAmrita Institute Medical Sciences, Kochi, India.
Thomas AlexanderKovai Medical Center and Hospital Research Foundation, Coimbatore, India.
Krishnan SwaminathanKovai Medical Center and Hospital Research Foundation, Coimbatore, India.
Rajeev GuptaEternal Heart Care Centre, Jaipur, India.
Ajit S MullasariMadras Medical Mission, Chennai, India.
Alben SigamaniNarayana Health, Bengaluru, India.
Muralidhar KanchiNarayana Health, Bengaluru, India.
Andrew S PetersonMedGenome Inc., Foster City, California.
Adam S ButterworthBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, United Kingdom.
John DaneshBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, United Kingdom; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, United Kingdom; National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, United Kingdom; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, United Kingdom; Department of Human Genetics, Wellcome Sanger Institute, Hinxton, United Kingdom.
Emanuele Di AngelantonioBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, United Kingdom.
Aliya NaheedInternational Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Michael InouyeCambridge Baker Systems Genomics Initiative, Melbourne, Victoria, Australia, and Cambridge, United Kingdom; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia; Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; Department of Clinical Pathology and School of BioSciences, University of Melbourne, Parkville, Victoria, Australia; The Alan Turing Institute, London, United Kingdom.
Rajiv ChowdhuryBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; Centre for Non-Communicable Disease Research, Dhaka, Bangladesh.
Ramprasad L VedamMedGenome Labs Ltd., Bengaluru, India.
Sekar KathiresanCardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts; Verve Therapeutics, Cambridge, Massachusetts.
Ravi GuptaMedGenome Labs Ltd., Bengaluru, India.
Amit V KheraCardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts; Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts; Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts. Electronic address: avkhera@mgh.harvard.edu.
SciGenom Labs (India) · INAmrita Institute of Medical Sciences and Research Centre · INBritish Heart Foundation · GBBroad Institute · USEternal Hospital · INNarayana Health · INKovai Medical Center and Hospital · INMassachusetts General Hospital · USBaker Heart and Diabetes Institute · AUInternational Centre for Diarrhoeal Disease Research · BDMadras Medical Mission · INNational Institute for Health Research · GB
Funding
Center for Common Disease GeneticsUM1HG008895 · NHGRI · BROAD INSTITUTE, INC. · PI DALY, MARK JOSEPH, GABRIEL, STACEY · 2016 to 2020
$111.2MMULTIDISCIPLINARY RESEARCH TRAINING IN CARDIOLOGYT32HL007208 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Patrick Thomas Ellinor, David E Sosnovik · 1985 to 2026
$16.1MPolygenic prediction of common, complex diseasesK08HG010155 · NHGRI · MASSACHUSETTS GENERAL HOSPITAL · PI KHERA, AMIT VIKRAM · 2018 to 2021
$1.1MMedical Research Council MC_PC_17228Medical Research Council MC_QA137853NHGRI NIH HHS K08 HG010155NHGRI NIH HHS UM1 HG008895NHLBI NIH HHS T32 HL007208
Abstract
backgroundGenome-wide polygenic scores (GPS) integrate information from many common DNA variants into a single number. Because rates of coronary artery disease (CAD) are substantially higher among South Asians, a GPS to identify high-risk individuals may be particularly useful in this population.
objectivesThis analysis used summary statistics from a prior genome-wide association study to derive a new GPS
methodsThis GPS
resultsThe GPS
conclusionsThe new GPS
Indexed as
Genome-Wide Association StudyMultifactorial InheritanceAdultAgedBangladeshCase-Control StudiesCoronary Artery DiseaseFemaleHumansIndiaMaleMiddle Agedcoronary artery diseasegenomic medicinepolygenic scoreSouth Asian
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.