ArticleeLife2020
Structural insights into the Ca
Open access · goldAbstract read
In one paragraph
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 70 citations in OpenAlex.
- Matrix polyamines regulate bidirectional calcium flux through MCU.Structure (London, England : 1993) · 2026Article
- Mechanistic Modeling of MCUx Gatekeeping, CaAmerican journal of physiology. Cell physiology · 2026Article
- The endometriosis-adenomyosis spectrum: shared pathophysiology and microenvironment-driven disease divergence.Reproductive biology and endocrinology : RB&E · 2026Review
- Mechanistic basis of EMRE's essential role in the regulation of mitochondrial calcium uniporter complex.bioRxiv : the preprint server for biology · 2026Article
- Reconstructing calcium conductance in MCUb illuminates its molecular design for tuning the mitochondrial calcium uniporter.Nature communications · 2026Article
- Mitochondrial CaCommunications biology · 2026Article
- Calmodulin enhancement of mitochondrial calcium uniporter function in isolated mitochondria.Cell calcium · 2025Article
- Structure of MICU from non-metazoan Dictyostelium discoideum reveals unique characteristics.Communications biology · 2025Article
- Mitochondrial Calcium Uniporter (MCU)-Mediated Calcium Overload in Psychoactive Drug Neurotoxicity: From Pathogenesis to Therapeutic Targets.International journal of molecular sciences · 2025Review
- MICU1's calcium sensing beyond mitochondrial calcium uptake.Biochimica et biophysica acta. Molecular cell research · 2024Review
- Article
- Mitochondrial calcium uniporter channel gatekeeping in cardiovascular disease.Nature cardiovascular research · 2024Review
- Patch-clamp technique to study mitochondrial membrane biophysics.The Journal of general physiology · 2023Article
- Reduced mitochondrial calcium uptake in macrophages is a major driver of inflammaging.Nature aging · 2023Article
- MICU1 controls the sensitivity of the mitochondrial CaCell chemical biology · 2023Article
- MICU1 occludes the mitochondrial calcium uniporter in divalent-free conditions.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- MICU1 regulates mitochondrial cristae structure and function independently of the mitochondrial CaScience signaling · 2023Article
- Evidence supporting the MICU1 occlusion mechanism and against the potentiation model in the mitochondrial calcium uniporter complex.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- From passage to inhibition: Uncovering the structural and physiological inhibitory mechanisms of MCUb in mitochondrial calcium regulation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023Review
- Mechanisms of ion selectivity and throughput in the mitochondrial calcium uniporter.Science advances · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Yan WangDepartment of Physiology, University of Texas Southwestern Medical Center, Dallas, United States.ORCID 0000-0001-8243-693X
Yan HanDepartment of Physiology, University of Texas Southwestern Medical Center, Dallas, United States.ORCID 0000-0002-1207-7756
Ji SheDepartment of Physiology, University of Texas Southwestern Medical Center, Dallas, United States.ORCID 0000-0001-7006-6230
Nam X NguyenDepartment of Physiology, University of Texas Southwestern Medical Center, Dallas, United States.
Vamsi K MoothaHoward Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Broad Institute, Cambridge, United States.ORCID 0000-0001-9924-642X
Xiao-Chen BaiDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, United States.ORCID 0000-0002-4234-5686
Youxing JiangDepartment of Physiology, University of Texas Southwestern Medical Center, Dallas, United States.ORCID 0000-0002-1874-0504
Howard Hughes Medical Institute · USThe University of Texas Southwestern Medical Center · USBroad Institute · US
Funding
Structural mechanisms of ion selectivity and gating in tetrameric cation channelsR01GM079179 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI JIANG, YOUXING · 2007 to 2019
$3.5MStructural and Functional Analyses of the Full-length Insulin Receptor (IR) and Type 1 Insulin-like Growth Factor Receptor (IGF1R) in the Liganded Active StateR01GM136976 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI BAI, XIAOCHEN · 2020 to 2024
$1.8MCancer Prevention and Research Institute of Texas RP160082Howard Hughes Medical InstituteNIGMS NIH HHS GM079179NIGMS NIH HHS GM136976NIGMS NIH HHS R01 GM079179NIGMS NIH HHS R01 GM136976Welch Foundation I-1578Welch Foundation I-1944
Abstract
Mitochondrial Ca
Indexed as
CalciumCalcium-Binding ProteinsCalcium ChannelsCation Transport ProteinsHumansMitochondrial Membrane Transport ProteinsModels, MolecularMultiprotein ComplexesProtein ConformationProtein MultimerizationCalciumCalcium-Binding ProteinsCalcium ChannelsCation Transport ProteinsMICU1 protein, humanMICU2 protein, humanmitochondrial calcium uniporterMitochondrial Membrane Transport ProteinsMultiprotein ComplexesSMDT1 protein, humanbiochemistryca2+-dependent gatingchemical biologycryo-EM structurehumanmitochondrial calcium uniportermolecular biophysicsstructural biology
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.