ArticleeLife2020
Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter
Open access · goldAbstract read
In one paragraph
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- Article
- Functional Studies of Kinetoplastid Transporters.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Interventions for Neglected Diseases Caused by Kinetoplastid Parasites: A One Health Approach to Drug Discovery, Development, and Deployment.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Uncovering the Unusual Inhibition Mechanism of a Trypanosome Alternative Oxidase Inhibitor Displaying Broad-Spectrum Activity against African Animal Trypanosomes.Journal of medicinal chemistry · 2025Article
- Antitrypanosomal and Antileishmanial Activities ofMolecules (Basel, Switzerland) · 2025Article
- Cytological profiling of trypanocidal principles fromPhytomedicine plus : international journal of phytotherapy and phytopharmacology · 2025Article
- Guanine derivatives as promising candidates for the development of purine-based antimalarial drugs.Frontiers in parasitology · 2025Article
- Exploring bioactive molecules released during inter- and intraspecific competition: A paradigm for novel antiparasitic drug discovery and design for human use.Current research in parasitology & vector-borne diseases · 2025Review
- Drug resistance in animal trypanosomiases: Epidemiology, mechanisms and control strategies.International journal for parasitology. Drugs and drug resistance · 2024Review
- Structural insights into drug transport by an aquaglyceroporin.Nature communications · 2024Article
- Synthesis and Biophysical and Biological Studies ofJournal of medicinal chemistry · 2023Article
- Tackling Sleeping Sickness: Current and Promising Therapeutics and Treatment Strategies.International journal of molecular sciences · 2023Review
- Cloning and Characterization ofInternational journal of molecular sciences · 2023Article
- The Activity of Red Nigerian Propolis and Some of Its Components againstMolecules (Basel, Switzerland) · 2023Article
- Differences in Transporters Rather than Drug Targets Are the Principal Determinants of the Different Innate Sensitivities ofInternational journal of molecular sciences · 2022Article
- Imidazoline- and Benzamidine-Based Trypanosome Alternative Oxidase Inhibitors: Synthesis and Structure-Activity Relationship Studies.ACS medicinal chemistry letters · 2022Article
- Article
- Evolution, function and roles in drug sensitivity of trypanosome aquaglyceroporins.Parasitology · 2021Article
- Activity of Compounds from Temperate Propolis againstMolecules (Basel, Switzerland) · 2021Article
- The Strong Anti-Kinetoplastid Properties of Bee Propolis: Composition and Identification of the Active Agents and Their Biochemical Targets.Molecules (Basel, Switzerland) · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
35 authors at 7 institutions in 4 countries.
Ali H AlghamdiInstitute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom.
Jane C MundayInstitute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom.
Gustavo Daniel CampagnaroInstitute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom.ORCID 0000-0001-6542-0485
Dominik GurvicComputational Biology Centre for Translational and Interdisciplinary Research, University of Dundee, Dundee, United Kingdom.
Fredrik SvenssonIOTA Pharmaceuticals Ltd, St Johns Innovation Centre, Cambridge, United Kingdom.
Chinyere E OkparaDepartment of Chemistry, University of Liverpool, Liverpool, United Kingdom.
Arvind KumarChemistry Department, Georgia State University, Atlanta, United States.
Juan QuintanaSchool of Life Sciences, University of Dundee, Dundee, United Kingdom.
Maria Esther Martin AbrilInstitute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom.
Patrik MilićInstitute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom.
Laura WatsonInstitute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom.
Daniel PaapeInstitute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom.
Luca SettimoInstitute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom.
Anna DimitriouInstitute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom.
Joanna WielinskaInstitute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom.
Graeme SmartInstitute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom.
Laura F AndersonInstitute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom.
Christopher M WoodleyDepartment of Chemistry, University of Liverpool, Liverpool, United Kingdom.
Siu Pui Ying KellyInstitute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom.
Hasan Ms IbrahimInstitute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom.
Fabian HulpiaLaboratory for Medicinal Chemistry, University of Ghent, Ghent, Belgium.ORCID 0000-0002-7470-3484
Mohammed I Al-SalabiInstitute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom.
Anthonius A EzeInstitute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom.ORCID 0000-0002-4821-1689
Teresa SprengerDepartment of Biochemistry, University of Cambridge, Cambridge, United Kingdom.
Ibrahim A TekaInstitute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom.
Simon GudinInstitute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom.
Simone WeyandDepartment of Biochemistry, University of Cambridge, Cambridge, United Kingdom.
Mark FieldSchool of Life Sciences, University of Dundee, Dundee, United Kingdom.
Christophe DardonvilleInstituto de Química Médica - CSIC, Madrid, Spain.
Richard R TidwellDepartment of Pathology and Lab Medicine, University of North Carolina at Chapel Hill, Chapel Hill, United States.
Mark CarringtonDepartment of Biochemistry, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0002-6435-7266
Paul O'NeillDepartment of Chemistry, University of Liverpool, Liverpool, United Kingdom.
David W BoykinChemistry Department, Georgia State University, Atlanta, United States.
Ulrich ZachariaeComputational Biology Centre for Translational and Interdisciplinary Research, University of Dundee, Dundee, United Kingdom.
Harry P De KoningInstitute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom.ORCID 0000-0002-9963-1827
University of Glasgow · GBUniversity of Dundee · GBUniversity of Cambridge · GBUniversity of Liverpool · GBGeorgia State University · USInstituto de Química Médica · ESUniversity of North Carolina at Chapel Hill · US
Funding
Molecular Design for Specific Recognition of Functional DNA SequencesR01GM111749 · NIGMS · GEORGIA STATE UNIVERSITY · PI WILSON, W DAVID · 2014 to 2021
$2.5MMedical Research Council 84733Medical Research Council G0701258Medical Research Council MR/R015791/1NIGMS NIH HHS R01 GM111749NIH HHS GM111749Science Without Borders, Brazil 206385/2014-5Wellcome 204697/Z/16/ZWellcome Trust
Abstract
Mutations in the
Indexed as
Aquaporin 2Trypanosoma brucei bruceiAnimalsAquaporinsDrug ResistanceMelarsoprolMutationPentamidineTrypanocidal AgentsTrypanosomiasis, AfricanAquaporin 2AquaporinsMelarsoprolPentamidineTrypanocidal Agentsaquaporinbiochemistrychemical biologydrug resistancedrug transportinfectious diseasemelarsoprolmicrobiologypentamidineTrypanosoma brucei
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.