ReviewDeutsches Arzteblatt international2020
Lipedema-Pathogenesis, Diagnosis, and Treatment Options.
Review in Deutsches Arzteblatt international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 105 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Reliability and Validity of the Turkish Version of the Lipedema Screening Questionnaire
Clinical Effects of TECAR Therapy in the Conservative Management of Lipedema: A Randomized Controlled Trial
Who cites it
105 citing papers in PubMed, 2 syntheses or guidelines pooled it, 194 citations in OpenAlex.
- Lipedema Diagnosis, Clinical Manifestations, and Therapeutics: A Systematic Review.International journal of dermatology · 2026Pooled it
- Lipedema: Progress, Challenges, and the Road Ahead.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Pooled it
- Lipedema and obesity: biological interactions, diagnostic challenges, and principles of interdisciplinary management - a narrative review.Adipocyte · 2026Review
- Obesity and Cardiovascular Disease: An Obesity Medicine Association (OMA) Clinical Practice Statement (CPS) 2026.Obesity pillars · 2026Review
- Lipoedema in an adolescent male following valproate discontinuation: a case report.Journal of rehabilitation medicine · 2026Article
- Lipoedema and Obesity Misclassification: A Phenotype Based Approach to Cardiometabolic Risk Beyond Body Mass Index.Clinical obesity · 2026Review
- Molecular Distinctions, Diagnosis, and Mechanism-Based Therapies in Lipedema and Obesity.Current issues in molecular biology · 2026Review
- Myocardial, Valvular, and Vascular Abnormalities in Lipedema.Reviews in cardiovascular medicine · 2026Review
- The Utility of Ultrasound in the Management of Lipedema: Preoperative, Intraoperative, and Postoperative Applications.Aesthetic plastic surgery · 2026Review
- Current Evidence-Based Clinical Nutritional Approaches in Lipedema: A Scoping Review.Nutrition reviews · 2026Article
- Article
- Reduced Serum Endostatin in Premenopausal Women with Lipedema Suggests Altered Vascular Homeostasis.Diseases (Basel, Switzerland) · 2026Article
- Lipedema Reframed: AFS Framework for Surgical and Transdisciplinary Management.Aesthetic plastic surgery · 2026Review
- Optimizing Liposuction in Lipedema Patients: A Novel Approach with Perioperative and Intraoperative Ultrasound.Aesthetic plastic surgery · 2026Article
- Postoperative Seroma in Lipedema Surgery: A Retrospective Analysis of 93 Cases from a Single Surgical Team.Aesthetic plastic surgery · 2026Observational
- Observational Study of Ultrasound-Assisted Liposuction for Lower Limb Lipedema on 191 Female Patients.Plastic and reconstructive surgery · 2026Observational
- Response to the Letter to the Editor: Improving Abdominal Lipedema Diagnosis with Lymphatic Imaging Validation and Standard-Based Clinical Implementation.Aesthetic plastic surgery · 2026Article
- Article
- Large-Volume Liposuction and Manual Extraction in Lipedema: A Hybrid approach.Aesthetic plastic surgery · 2026Article
- The Role of Helium Plasma Technology in Liposuction for Lipedema of the Lower Limbs: A Stage-Specific Analysis.Aesthetic plastic surgery · 2026Article
45 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLipedema is often unrecognized or misdiagnosed; despite an estimated prevalence of 10% in the overall female population, its cause is still unknown. There is increasing awareness of this condition, but its differential diagnosis can still be challenging. In this article, we summarize current hypotheses on its pathogenesis and the recommendations of current guidelines for its diagnosis and treatment.
methodsThis review is based on publications about lipedema that were retrieved by a selective search in the MEDLINE, Web of Science, and Cochrane Library databases.
resultsThe pathophysiology of lipedema remains unclear. The putative causes that have been proposed include altered adipogenesis, microangiopathy, and disturbed lymphatic microcirculation. No specific biomarker has yet been found, and the diagnosis is currently made on clinical grounds alone. Ancillary tests are used only to rule out competing diagnoses. The state of the evidence on treatment is poor. Treatment generally consists of complex decongestive therapy. In observational studies, liposuction for the permanent reduction of adipose tissue has been found to relieve symptoms to a significant extent, with only rare complications. The statutory healthinsurance carriers in Germany do not yet regularly cover the cost of the procedure; studies of high methodological quality will be needed before this is the case.
conclusionThe diagnosis of lipedema remains a challenge because of the hetero - geneous presentation of the condition and the current lack of objective measuring instruments to characterize it. This review provides a guide to its diagnosis and treatment in an interdisciplinary setting. Research in this area should focus on the elucidation of the pathophysiology of lipedema and the development of a specific biomarker for it.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.