Evidence map›Paper›PMID 32762760›Full record

ArticleRetrovirology2020

Longitudinal analysis of subtype C envelope tropism for memory CD4

Matthew J Gartner, Paul R Gorry, Carolin Tumpach, Jingling Zhou, Ashanti Dantanarayana, J Judy Chang, Thomas A Angelovich, Paula Ellenberg, Annemarie E Laumaea, Molati Nonyane and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Retrovirology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Targeting HIV-1 reservoirs in T cell subsets.Frontiers in immunology · 2023
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 3 countries.

Matthew J GartnerSchool of Health and Biomedical Sciences, RMIT University, Bundoora, Melbourne, VIC, Australia.
Paul R GorrySchool of Health and Biomedical Sciences, RMIT University, Bundoora, Melbourne, VIC, Australia.
Carolin TumpachThe Peter Doherty Institute for Infection and Immunity, University of Melbourne and Royal Melbourne Hospital, Melbourne, VIC, Australia.
Jingling ZhouSchool of Health and Biomedical Sciences, RMIT University, Bundoora, Melbourne, VIC, Australia.
Ashanti DantanarayanaThe Peter Doherty Institute for Infection and Immunity, University of Melbourne and Royal Melbourne Hospital, Melbourne, VIC, Australia.
J Judy ChangThe Peter Doherty Institute for Infection and Immunity, University of Melbourne and Royal Melbourne Hospital, Melbourne, VIC, Australia.
Thomas A AngelovichSchool of Health and Biomedical Sciences, RMIT University, Bundoora, Melbourne, VIC, Australia.
Paula EllenbergThe Peter Doherty Institute for Infection and Immunity, University of Melbourne and Royal Melbourne Hospital, Melbourne, VIC, Australia.
Annemarie E LaumaeaSchool of Health and Biomedical Sciences, RMIT University, Bundoora, Melbourne, VIC, Australia.
Molati NonyaneCentre for HIV and STIs, National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), Johannesburg, South Africa.
Penny L MooreCentre for HIV and STIs, National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), Johannesburg, South Africa.
Sharon R LewinThe Peter Doherty Institute for Infection and Immunity, University of Melbourne and Royal Melbourne Hospital, Melbourne, VIC, Australia.
Melissa J ChurchillSchool of Health and Biomedical Sciences, RMIT University, Bundoora, Melbourne, VIC, Australia.
Jacqueline K FlynnSchool of Health and Biomedical Sciences, RMIT University, Bundoora, Melbourne, VIC, Australia. Jacqueline.Flynn@unimelb.edu.au.
Michael RocheSchool of Health and Biomedical Sciences, RMIT University, Bundoora, Melbourne, VIC, Australia. Michael.roche@rmit.edu.au.ORCID 0000-0001-8819-0096
The Royal Melbourne Hospital · AURMIT University · AUNational Health Laboratory Service · ZABurnet Institute · AUUniversité de Montréal · CA

Funding

NIMHD NIH HHS L60 MD003100
6 · The paper itself

Abstract

backgroundHIV-1 infects a wide range of CD4

resultsA total of 50 C-HIV envs were cloned and screened for functionality in pseudovirus infection assays. Phylogenetic and variable region characteristic analysis demonstrated evolution in envs between time points. We found 45 pseudoviruses were functional and all used CCR5 to mediate entry into NP2/CD4/CCR5 cells. In vitro infection assays showed transitional memory (TM) and effector memory (EM) CD4

conclusionsCD4

Indexed as

Viral TropismAdultCD4-Positive T-Lymphocytesenv Gene Products, Human Immunodeficiency VirusFemaleGenetic VariationHIV-1HIV InfectionsHumansImmunologic MemoryLongitudinal StudiesPhylogenyReceptors, HIVT-Lymphocyte Subsetsenv Gene Products, Human Immunodeficiency VirusReceptors, HIVCD4+ T cellsCellular tropismCoreceptor usageEnvelopeSubtype C HIV-1

Identifiers

PMID32762760
PMCPMC7409430
OpenAlexW3048319352

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.