Evidence map›Paper›PMID 32762675›Full record

ArticleBMC ophthalmology2020

Role of complement factor B rs4151667 (L9H) polymorphisms and its interactional role with CFH Y402H and C3 rs2230199 (R102G) risk variants in age-related macular degeneration: a case control study.

Nasrin Roshanipour, Maryam Ghaffari Laleh, Mortaza Bonyadi, Mohammad Hossein Jabbarpoor Bonyadi, Masoud Soheilian, Alireza Javadzadeh, Mehdi Yaseri

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Article in BMC ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Nasrin RoshanipourDepartment of Biology, Tabriz Branch Islamic Azad University, Tabriz, Iran.
Maryam Ghaffari LalehCenter of Excellence for Biodiversity, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
Mortaza BonyadiCenter of Excellence for Biodiversity, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran. bonyadijm@yahoo.com.ORCID http://orcid.org/0000-0003-3216-2947
Mohammad Hossein Jabbarpoor BonyadiOcular Tissue Engineering Research Center, Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Masoud SoheilianOcular Tissue Engineering Research Center, Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Alireza JavadzadehDepartment of Ophthalmology, Tabriz University of Medical Sciences, Tabriz, Iran.
Mehdi YaseriDepartment of Biostatistics and Epidemiology, Tehran University of Medical Sciences, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAge-related Macular Degeneration (AMD) is a complex eye disease, which is genetically associated with different susceptibility loci. We planned to investigate the possible association of Complement Factor B (CFB) rs4151667 (L9H) variants and their possible interaction with Complement Factor H (CFH) Y402H and Complement factor 3 (C3) rs2230199 (R102G) in AMD.

methodsThis case-control association study included 216 advanced type AMD patients and 191 healthy individuals for evaluation. Extracted-DNA samples were genotyped for the polymorphic regions of CFB rs4151667 (L9H), CFH Y402H and C3 rs2230199 (R102G).

resultsThe distribution of CFB rs4151667 (L9H) genotypes was not significantly different in the AMD patients compared to that of controls (P = 0.18). The AT genotype frequencies for CFB was non significantly lower in AMD group (6.5% vs. 13.1%, AOR = 0.49, CI = 0.23-1.04, P = 0.064(. The A allele of CFB rs4151667 (L9H) was found to be non-significantly lower in AMD patients. CFB rs4151667 (L9H) had no protective interactional effect against CFH (Y402H) and C3 (R102G) risk variants.

conclusionsThis study showed that the protective role of CFB rs4151667 (L9H) in AMD is not significant and it has no significant protective interactional effect against CFH (Y402H) and C3 (R102G) risk variants.

Indexed as

Complement Factor BMacular DegenerationCase-Control StudiesComplement C2Complement Factor HGene FrequencyGenotypeHumansPolymorphism, Single NucleotideComplement C2Complement Factor BComplement Factor HAge-related macular degeneration (AMD)Complement factor 3 (C3) geneComplement factor B (CFB) geneComplement factor H (CFH) geneL9H polymorphismsPCR-RFLPR102G polymorphismY402H polymorphism

Identifiers

PMID32762675
PMCPMC7409625

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