ArticleThe Journal of international medical research2020
Bioavailable testosterone is associated with symptoms of depression in adult men.
Article in The Journal of international medical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Exploring the Causal Relationship Between Sex Hormones and Depression by Means of Two-Sample Mendelian Randomization Analysis.Actas espanolas de psiquiatria · 2026Article
- Alterations in Gut Microbiota and Serum Metabolome Are Associated with Postpartum Depression.Nutrients · 2026Article
- Associations between outdoor light exposure and low muscle mass: An NHANES 2011 to 2014 analysis.Medicine · 2026Article
- The Association of Low Muscle Mass With Serum Sex Hormones and Sex Hormone-Binding Globulin.Journal of cachexia, sarcopenia and muscle · 2025Article
- Adaptations in Mitochondrial Function Induced by Exercise: A Therapeutic Route for Treatment-Resistant Depression.International journal of molecular sciences · 2025Review
- The Metabolic Syndrome, a Human Disease.International journal of molecular sciences · 2024Review
- Role of sex hormone-binding globulin in the free hormone hypothesis and the relevance of free testosterone in androgen physiology.Cellular and molecular life sciences : CMLS · 2022Review
- An LC/MS/MS method for quantifying testosterone and dehydroepiandrosterone sulfate in four different serum samples during a single run.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2022Article
- Baicalin Attenuates Continuous Activation ofEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Oncofertility in pediatric patients: current perspectives.Contemporary oncology (Poznan, Poland) · 2022Review
- Association between Serum Testosterone Levels and Body Composition among Men 20-59 Years of Age.International journal of endocrinology · 2021Article
- Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to determine the relationship between serum testosterone levels and depressive symptoms in an adult male population.
methodsWe conducted a cross-sectional study of 1166 male participants from Zunyi, Guizhou, China. Each participant completed a questionnaire, a brief clinical exam, and had a fasting blood sample taken. We measured serum testosterone, sex hormone-binding globulin, and luteinizing hormone levels. Multiple linear regression was used to evaluate the effect of demographic factors on the relationship between the depressive symptom score and serum sex hormone levels.
resultsMean testosterone, sex hormone-binding globulin, and luteinizing hormone levels were significantly higher in the depressive symptom group than in the non-depressed group. The mean calculated free serum testosterone level and free testosterone index (FTI) were significantly lower in the depressive symptom group than in the non-depressed group. Additionally, the mean FTI was significantly negatively correlated with the Beck Depression Inventory scale score in the multiple linear regression model (95% confidence interval: -3.274 to -0.406).
conclusionsDecreased bioactive testosterone levels might be a contributing factor of depression in adult men. The FTI could be the most sensitive biomarker reflecting the level of bioavailable testosterone in patients with depression.
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Registered trials
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