ArticleAging cell2020
Plasma proteomic profile of frailty.
Article in Aging cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Proteome-wide profiling reveals dysregulated molecular features and accelerated aging in osteoporosis: A 9.8-year prospective study.Aging cell · 2024Pooled it
- Aptamer-Based Platforms for Human Aging Biomarkers: Multiplexed Proteomics, Biosensors and Translational Perspectives.International journal of molecular sciences · 2026Review
- Cell death-induced release of the pro-aging protein acyl CoA binding protein (ACBP) into the circulation.Cell death and differentiation · 2026Article
- The Application of Metabolomics in Frailty: Trends, Challenges, and Future Directions.Metabolites · 2026Review
- Plasma metabolomic and inflammatory profiles associated with low physical function in heart failure: an integrated cardiac-metabolic-muscular phenotype.GeroScience · 2026Article
- ProtFI, an efficient frailty-trained proteomics-based biomarker of aging, robustly predicts age-related decline.Cell reports methods · 2026Article
- Associations of 6600 SomaScan proteins with demographic, lifestyle, environmental and health characteristics in Chinese adults.Scientific reports · 2026Article
- Plasma Proteomic Profiling of Young and Older Adults Identifies Candidate Biomarkers of Biological Aging at the Intersection of Age and Disease.Aging cell · 2026Article
- Association Between Frailty and Leptin Levels in Patients with Stable Coronary Artery Disease.Diagnostics (Basel, Switzerland) · 2026Article
- A Preliminary Predictive Panel for Pre-Frailty Based on Serum Proteomic Biomarkers: A Two-Phase Cross-Sectional Study.Clinical interventions in aging · 2026Article
- The effect of long-term adherence to physical activity recommendations in midlife on plasma proteins associated with frailty in the Atherosclerosis Risk in Communities (ARIC) study.European journal of epidemiology · 2026Article
- A Frailty-Based Plasma Proteomic Signature Capturing Overall Health and Well-Being in Older Adults.Aging cell · 2025Article
- Differential proteomic profiles between cognitive frail and robust older adults from the MELoR cohort.GeroScience · 2025Article
- Proteo-metabolomic insights for early dual physical and cognitive impairments: A search for biomarkers of healthy aging based on muscle-brain crosstalk.Aging cell · 2025Article
- The combination of fatigue with the serum GCSF improves the performance of serological screening for frailty.Acta biochimica et biophysica Sinica · 2025Article
- Geroscience in heart failure: the search for therapeutic targets in the shared pathobiology of human aging and heart failure.The journal of cardiovascular aging · 2025Article
- Revealing age-related changes in the intraocular microenvironment and senescence modulators using aqueous humor proteomics and machine learning.Frontiers in cell and developmental biology · 2025Article
- A unified metric of human immune health.Nature medicine · 2024Article
- Associations of plasma proteomics and age-related outcomes with brain age in a diverse cohort.GeroScience · 2024Article
- Cerebrospinal fluid proteomic profile of frailty: Results from the PROLIPHYC cohort.Aging cell · 2024Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Frailty is a state of decreased physiological reserve and increased vulnerability to adverse outcomes in aging, and is characterized by dysregulation across various biological pathways. Frailty may manifest biologically as alteration in protein expression, possibly regulated at genetic, transcriptional and epigenetic levels. In this study, we examined the proteomic profile associated with frailty defined by an established cumulative frailty index (FI). Using the SomaScan
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.