Evidence map›Paper›PMID 32761803›Full record

ArticleJournal of cellular and molecular medicine2020

Low-energy shock wave pretreatment recruit circulating endothelial progenitor cells to attenuate renal ischaemia reperfusion injury.

Jingyu Liu, Quanliang Dou, Changcheng Zhou, Liuhua Zhou, Feng Zhao, Luwei Xu, Zheng Xu, Yuzheng Ge, Ran Wu, Ruipeng Jia

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Endothelial Progenitor Cells: Disease Markers and Potential Therapy in Kidney Disease.Journal of the American Society of Nephrology : JASN · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Jingyu LiuDepartment of Urology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.ORCID 0000-0001-9692-6374
Quanliang DouDepartment of Urology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Changcheng ZhouDepartment of Urology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Liuhua ZhouDepartment of Urology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Feng ZhaoDepartment of Urology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Luwei XuDepartment of Urology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Zheng XuDepartment of Urology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Yuzheng GeDepartment of Urology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Ran WuDepartment of Urology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Ruipeng JiaDepartment of Urology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Nanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Low-energy shock wave (LESW) has been recognized as a promising non-invasive intervention to prevent the organs or tissues against ischaemia reperfusion injury (IRI), whereas its effect on kidney injury is rarely explored. To investigate the protective role of pretreatment with LESW on renal IRI in rats, animals were randomly divided into Sham, LESW, IRI and LESW + IRI groups. At 4, 12, 24 hours and 3 and 7 days after reperfusion, serum samples and renal tissues were harvested for performing the analysis of renal function, histopathology, immunohistochemistry, flow cytometry and Western blot, as well as enzyme-linked immunosorbent assay. Moreover, circulating endothelial progenitor cells (EPCs) were isolated, labelled with fluorescent dye and injected by tail vein. The fluorescent signals of EPCs were detected using fluorescence microscope and in vivo imaging system to track the distribution of injected circulating EPCs. Results showed that pretreatment with LESW could significantly reduce kidney injury biomarkers, tubular damage, and cell apoptosis, and promote cell proliferation and vascularization in IRI kidneys. The renoprotective role of LESW pretreatment would be attributed to the remarkably increased EPCs in the treated kidneys, part of which were recruited from circulation through SDF-1/CXCR7 pathway. In conclusion, pretreatment with LESW could increase the recruitment of circulating EPCs to attenuate and repair renal IRI.

Indexed as

Extracorporeal Shockwave TherapyAnimalsApoptosisCell MovementChemokine CXCL12Endothelial Progenitor CellsFluorescent DyesIn Situ Nick-End LabelingKidneyMaleMicroscopy, FluorescenceMicrovesselsRandom AllocationRatsRats, Sprague-DawleyReceptors, CXCRAckr3 protein, ratChemokine CXCL12CXCL12 protein, ratFluorescent DyesReceptors, CXCRC-X-C chemokine receptor type 7endothelial progenitor cellsischaemia reperfusion injurylow-energy shock wavestromal cell-derived factor 1

Identifiers

PMID32761803
PMCPMC7521246
OpenAlexW3047920315

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.