ArticlePediatric obesity2021
Associations of DXA-measured abdominal adiposity with cardio-metabolic risk and related markers in early adolescence in Project Viva.
Article in Pediatric obesity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.
- Leptin, CRP, and adiponectin correlate with body fat percentage in adolescents: systematic review and meta-analysis.Frontiers in nutrition · 2025Pooled it
- Racial-Ethnic Disparities in Obesity and Biological, Behavioral, and Sociocultural Influences in the United States: A Systematic Review.Advances in nutrition (Bethesda, Md.) · 2021Pooled it
- Joint Associations of Prenatal Per- and Polyfluoroalkyl Substances and Metal Mixtures with Adiposity in Childhood and Adolescence.Environmental science & technology · 2026Article
- The role of genetic polymorphisms in pediatric metabolic syndrome: the role of fat mass and obesity-associated (FTO) gene.Pediatric research · 2026Article
- Review on the Relationship Between TyG Index and CVD Incidence in Patients With T2DM With NAFLD.International journal of endocrinology · 2026Review
- Maternal allostatic load in pregnancy is prospectively associated with child adiposity and metabolic function across infancy and early childhood.Psychoneuroendocrinology · 2025Article
- Obesity and central accumulation of fat in school-age children with attention-deficit/hyperactivity disorder.Scientific reports · 2025Article
- The Interplay Between Visceral Adiposity and Cardiometabolic Risk in Children With Obesity.Cureus · 2025Article
- Emerging Perspectives on the Set of Conditions That Lead to the Emergence of Metabolic Syndrome.Journal of personalized medicine · 2023Review
- Visceral fat and cardiometabolic future in children and adolescents: a critical update.Pediatric research · 2023Review
- Monitoring body composition change for intervention studies with advancing 3D optical imaging technology in comparison to dual-energy X-ray absorptiometry.The American journal of clinical nutrition · 2023Article
- Associations of maternal insulin sensitivity during pregnancy with childhood central adiposity in the Genetics of Glucose regulation in Gestation and Growth (Gen3G) cohort.Pediatric obesity · 2023Article
- A Mini-Review of Pediatric Anthropometrics as Predictors of Future Insulin Resistance.Frontiers in endocrinology · 2022Review
- Associations of midchildhood to early adolescence central adiposity gain with cardiometabolic health in early adolescence.Obesity (Silver Spring, Md.) · 2021Article
- Association of Mode of Obstetric Delivery With Child and Adolescent Body Composition.JAMA network open · 2021Article
- Longitudinal associations of fruit juice intake in infancy with DXA-measured abdominal adiposity in mid-childhood and early adolescence.The American journal of clinical nutrition · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundIncreased visceral adipose tissue (VAT) precedes development of insulin resistance and dyslipidemia in adults. The associations of abdominal adiposity derived from dual-energy X-ray absorptiometry (DXA), including VAT, subcutaneous abdominal adipose tissue (SAAT) and total abdominal adipose tissue (TAAT) with cardio-metabolic risk in adolescents are understudied.
objectivesWe examined the cross-sectional associations of DXA-measured abdominal adiposity with cardio-metabolic risk and related markers in early adolescence (mean [SD] age 13.0 [0.7] years).
methodsWe collected data from 740 adolescents (374 girls and 366 boys) in Project Viva, a U.S. pre-birth cohort. We used DXA estimates of VAT, SAAT and TAAT area. We conducted overall and sex-stratified linear regression models, adjusting for age, sex (in overall models), race/ethnicity, puberty score and body mass index (BMI) z-score.
resultsMean BMI z-score was 0.59 (1.28). After adjustment, greater VAT (per 1 SD score) was associated with higher metabolic risk z-score (β 0.14 units; 95% CI 0.08, 0.20), higher log high-sensitivity C-reactive protein (β 0.51 mg/L; 0.36, 0.66) and log leptin (β 0.36 ng/mL; 0.27, 0.44), and lower log adiponectin (β -0.08 ug/mL; -0.13, -0.02). SAAT and TAAT showed similar associations as VAT with comparable or greater effect sizes.
conclusionIn early adolescence, DXA-measured VAT, SAAT and TAAT are associated with cardio-metabolic risk and related markers, independent of current BMI. Among two adolescents with the same BMI, there is an associated higher cardio-metabolic risk in the adolescent with greater DXA-measured abdominal adiposity.
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Registered trials
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