ArticleAdvanced healthcare materials2021
Microfabricated Gaps Reveal the Effect of Geometrical Control in Wound Healing.
Article in Advanced healthcare materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Cell type-specific response to curvature controls tissue growth dynamics in biomaterial pores.Bioactive materials · 2026Article
- Advances in micropatterning technology for mechanotransduction research.Mechanobiology in medicine · 2024Review
- A Roadmap from Functional Materials to Plant Health Monitoring (PHM).Macromolecular bioscience · 2024Review
- Dissecting the influence of cellular senescence on cell mechanics and extracellular matrix formation in vitro.Aging cell · 2023Article
- The Effect of Geometry and TGF-β Signaling on Tumor Cell Migration from Free-Standing Microtissues.Advanced healthcare materials · 2022Article
- Directing Multicellular Organization by Varying the Aspect Ratio of Soft Hydrogel Microwells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Extracellular Matrix Alignment Directs Provisional Matrix Assembly and Three Dimensional Fibrous Tissue Closure.Tissue engineering. Part A · 2021Article
- Microfabricated Gaps Reveal the Effect of Geometrical Control in Wound Healing.Advanced healthcare materials · 2021Article
- Engineered Microsystems for Spheroid and Organoid Studies.Advanced healthcare materials · 2021Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The geometry (size and shape) of gaps is a key determinant in controlling gap closure during wound healing. However, conventional methods for creating gaps result in un-defined geometries and poorly characterized conditions (cell death factors and cell debris), which can influence the gap closure process. To overcome these limitations, a novel method to create well-defined geometrical gaps is developed. First, smooth muscle cells (SMCs) are seeded in variously shaped micro-containers made out of hyaluronic acid hydrogels. Cell proliferation and cell tension induce fibrous collagen production by SMCs predominantly around the edges of the micro-containers. Upon removal of SMCs, the selectively deposited collagen results in micro-containers with cell-adhesive regions along the edges and walls. Fibroblasts are seeded in these micro-containers, and upon attaching and spreading, they naturally form gaps with different geometries. The rapid proliferation of fibroblasts from the edge results in filling and closure of the gaps. It is demonstrated that gap closure rate as well as closure mechanism is strongly influenced by geometrical features, which points to an important role for cellular tension and cell proliferation in gap closure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.