Evidence map›Paper›PMID 32761646›Full record

ArticleEnvironmental and molecular mutagenesis2020

Assessment of systemic genetic damage in pediatric inflammatory bowel disease.

Ayesha Baig, Svetlana L Avlasevich, Dorothea K Torous, Jeffrey C Bemis, Lawrence J Saubermann, David P Lovell, James T MacGregor, Stephen D Dertinger

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental and molecular mutagenesis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Physiological Significance and Functions of AA.Reviews of physiology, biochemistry and pharmacology · 2027
    Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Ayesha BaigDepartment of Pediatrics, University of Rochester Medical Center, Rochester, New York, USA.
Svetlana L AvlasevichLitron Laboratories, Rochester, New York, USA.
Dorothea K TorousLitron Laboratories, Rochester, New York, USA.
Jeffrey C BemisLitron Laboratories, Rochester, New York, USA.
Lawrence J SaubermannDepartment of Pediatrics, University of Rochester Medical Center, Rochester, New York, USA.
David P LovellSt. George's University of London, London Borough of Wandsworth, UK.
James T MacGregorToxicology Consulting Services, Bonita Springs, Florida, USA.
Stephen D DertingerLitron Laboratories, Rochester, New York, USA.
Litron Laboratories (United States) · USUniversity of Rochester Medical Center · USBiological Consulting Services (United States) · USSt George's, University of London · GB

Funding

Validation of Cross-Species Biomarkers of DNA DamageR44ES028163 · NIEHS · LITRON LABORATORIES, LTD. · PI BEMIS, JEFFREY C, DERTINGER, STEPHEN D · 2018 to 2019
$1.4M
NIEHS NIH HHS R44 ES028163
6 · The paper itself

Abstract

The etiology of distal site cancers in inflammatory bowel disease (IBD) is not well understood and requires further study. We investigated whether pediatric IBD patients' blood cells exhibit elevated levels of genomic damage by measuring the frequency of mutant phenotype (CD59-/CD55-) reticulocytes (MUT RET) as a reporter of PIG-A mutation, and the frequency of micronucleated reticulocytes (MN-RET) as an indicator of chromosomal damage. IBD patients (n = 18 new-onset disease, 46 established disease) were compared to age-matched controls (constipation or irritable bowel syndrome patients from the same clinic, n = 30) and young healthy adults age 19-24 (n = 25). IBD patients showed no indication of elevated MUT RET relative to controls (mean ± SD = 3.1 ± 2.3 × 10

Indexed as

Micronuclei, Chromosome-DefectiveMutationAdolescentAdultAntigens, CDCD59 AntigensCell Adhesion MoleculesChildFemaleHumansInflammatory Bowel DiseasesMaleMembrane ProteinsMicronucleus TestsReticulocytesYoung AdultAntigens, CDCD59 AntigensCD59 protein, humanCell Adhesion MoleculesICAM3 protein, humanMembrane Proteinsphosphatidylinositol glycan-class A proteinchromosomal damagegenotoxicity; flow cytometryinflammatory bowel diseasemutation

Identifiers

PMID32761646
PMCPMC8597720
OpenAlexW3048234703

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.