Evidence map›Paper›PMID 32761610›Full record

ArticleInternational journal of cancer2021

Genetically predicted circulating concentrations of micronutrients and risk of breast cancer: A Mendelian randomization study.

Nikos Papadimitriou, Niki Dimou, Dipender Gill, Ioanna Tzoulaki, Neil Murphy, Elio Riboli, Sarah J Lewis, Richard M Martin, Marc J Gunter, Konstantinos K Tsilidis

Open access · greenAbstract read
In one paragraph

Article in International journal of cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 4 pooled it
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 4 syntheses or guidelines pooled it, 52 citations in OpenAlex.

  1. Causal inference in the diagnosis and prognosis of ovarian cancer: current state and future directions.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
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  17. Micronutrient Status and Breast Cancer: A Narrative Review.International journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Nikos PapadimitriouDepartment of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece.
Niki DimouDepartment of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece.
Dipender GillDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Ioanna TzoulakiDepartment of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece.
Neil MurphySection of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France.ORCID 0000-0003-3347-8249
Elio RiboliDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Sarah J LewisDepartment of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Richard M MartinDepartment of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Marc J GunterSection of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France.
Konstantinos K TsilidisDepartment of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece.ORCID 0000-0002-8452-8472
University of Ioannina · GRCentre international de recherche sur le cancer · FRImperial College London · GBUniversity Hospitals Bristol NHS Foundation Trust · GBUniversity of Bristol · GB

Funding

Molecular pathological epidemiology of colorectal cancerU01CA137088 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PETERS, ULRIKE · 2009 to 2018
$21.8M
Genome-Wide Association Study of Nonsynonymous SNPs in Colon CancerR01CA059045 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PETERS, ULRIKE · 1994 to 2011
$11.5M
Epidemiologic StudiesU19CA148065 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI AHSAN, HABIBUL, BRUGGE, JOAN SIEFERT · 2010 to 2014
$10.6M
Using Functional Genomics to Inform Gene Environment Interactions for Colorectal CancerR01CA201407 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI CASEY, GRAHAM, GAUDERMAN, WILLIAM JAMES · 2016 to 2020
$9.6M
Cancer Research UK 19169Cancer Research UK 29019Cancer Research UK C1287/A10118Cancer Research UK C1287/A10710Cancer Research UK C1287/A16563Cancer Research UK C18281/A19169NCI NIH HHS R01 CA059045NCI NIH HHS R01 CA201407NCI NIH HHS U01 CA137088NCI NIH HHS U19 CA148065NIH HHS U19 CA148065NIH HHS X01HG007492World Health Organization 001
6 · The paper itself

Abstract

The epidemiological literature reports inconsistent associations between consumption or circulating concentrations of micronutrients and breast cancer risk. We investigated associations between genetically predicted concentrations of 11 micronutrients (beta-carotene, calcium, copper, folate, iron, magnesium, phosphorus, selenium, vitamin B

Indexed as

Polymorphism, Single NucleotideBreast NeoplasmsCase-Control StudiesFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMagnesiumMendelian Randomization AnalysisMicronutrientsMolecular EpidemiologyPhosphorusReceptors, EstrogenMagnesiumMicronutrientsPhosphorusReceptors, Estrogenbreast cancercausal inferencedietMendelian randomizationnutrition

Identifiers

PMID32761610
PMCPMC8268064
OpenAlexW3047739951

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.