Evidence map›Paper›PMID 32761557›Full record

ArticleAnnals of biomedical engineering2021

Virus-Mimicking Nanoparticles for Targeted Near Infrared Fluorescence Imaging of Intraperitoneal Ovarian Tumors in Mice.

Raviraj Vankayala, Edver Bahena, Yadir Guerrero, Sheela P Singh, Murali K Ravoori, Vikas Kundra, Bahman Anvari

Abstract read
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In one paragraph

Article in Annals of biomedical engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Cell-Based Tracers as Trojan Horses for Image-Guided Surgery.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Raviraj VankayalaDepartment of Bioengineering, University of California, Riverside, 900 University Avenue, Riverside, CA, 92521, USA.
Edver BahenaDepartment of Bioengineering, University of California, Riverside, 900 University Avenue, Riverside, CA, 92521, USA.
Yadir GuerreroDepartment of Bioengineering, University of California, Riverside, 900 University Avenue, Riverside, CA, 92521, USA.
Sheela P SinghDepartment of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Murali K RavooriDepartment of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Vikas KundraDepartment of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Bahman AnvariDepartment of Bioengineering, University of California, Riverside, 900 University Avenue, Riverside, CA, 92521, USA. anvarib@ucr.edu.ORCID http://orcid.org/0000-0002-2511-5854
University of California, Riverside · USThe University of Texas MD Anderson Cancer Center · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
Division of Chemical, Bioengineering, Environmental, and Transport Systems 1402353Division of Chemical, Bioengineering, Environmental, and Transport Systems 1403191
6 · The paper itself

Abstract

Ovarian cancer is the most lethal malignancy affecting the female reproductive system. Identification and removal of all ovarian intraperitoneal tumor deposits during the intraoperative surgery is important towards preventing cancer recurrence and ultimately improving patient survival. Herein, we investigate the effectiveness of virus mimicking nanoparticles, derived from genome-depleted plant-infecting brome mosaic virus, and doped with near infrared (NIR) brominated cyanine dye BrCy106-NHS, for targeted NIR fluorescence imaging of intraperitoneal ovarian tumors. We refer to these nanoparticles as optical viral ghosts (OVGs). We functionalized the OVGs with antibodies against HER2 receptor, a biomarker over-expressed in ovarian cancers. We injected functionalized OVGs, non-functionalized OVGs, and non-encapsulated BrCy106-NHS intravenously in mice implanted with ovarian intraperitoneal tumors. Tumors were extracted at 2, 6, and 24 h post-injection, and quantitatively analyzed using NIR fluorescence imaging. Fluorescence emission from tumors associated with the injection of the functionalized OVGs continued to increase between 2 and 24 h post-injection. At 24 h timepoint, the average spectrally-integrated fluorescence emission from homogenized tumors containing functionalized-OVGs was about 3.5 and 19.5 times higher than those containing non-functionalized OVGs or non-encapsulated BrCy106-NHS, respectively. Similarly, by using the functionalized-OVGs, the imaging signal-to-noise ratio at 24 h timepoint was enhanced by approximately threefold and sevenfold as compared to non-functionalized OVGs and the non-encapsulated dye, respectively. These functionalized virus-mimicking NIR nano-constructs could potentially be used for intraoperative visualization of ovarian tumors implants.

Indexed as

BromovirusErb-b2 Receptor Tyrosine KinasesAnimalsCell Line, TumorFemaleFluorescent DyesHumansMiceMice, NudeNanoparticlesOptical ImagingOvarian NeoplasmsPeritoneal NeoplasmsTransplantation, HeterologousErb-b2 Receptor Tyrosine KinasesFluorescent DyesBrome mosaic virusCyanine dyesImage guided surgeryIntraoperative optical imagingPlant viruses

Identifiers

PMID32761557
OpenAlexW3047221718

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.