Article3D printing in medicine2020
Method to simulate distal flow resistance in coronary arteries in 3D printed patient specific coronary models.
Article in 3D printing in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Development and Characteristics of a Dual-Layered Vascular Phantom.Cardiovascular engineering and technology · 2026Article
- Evaluating 3D Hand Scanning Accuracy Across Trained and Untrained Students.Bioengineering (Basel, Switzerland) · 2025Article
- A comparative study between CT angiography and flow parameters in hemodynamic phantom of carotid stenosis evaluated by duplex sonography.3D printing in medicine · 2025Article
- Synthetic 3D printed tibial plateau with gradient material properties for biomechanical accuracy.Frontiers in bioengineering and biotechnology · 2025Article
- Cardiovascular Computed Tomography in the Diagnosis of Cardiovascular Disease: Beyond Lumen Assessment.Journal of cardiovascular development and disease · 2024Review
- Three-Dimensional Bioprinting in Cardiovascular Disease: Current Status and Future Directions.Biomolecules · 2023Review
- Patient-Specific 3D-Printed Low-Cost Models in Medical Education and Clinical Practice.Micromachines · 2023Review
- 3D Printed Models in Cardiovascular Disease: An Exciting Future to Deliver Personalized Medicine.Micromachines · 2022Review
- Comparison of fluid dynamics changes due to physical activity in 3D printed patient specific coronary phantoms with the Windkessel equivalent model of coronary flow.3D printing in medicine · 2022Article
- Development of Custom Wall-Less Cardiovascular Flow Phantoms with Tissue-Mimicking Gel.Cardiovascular engineering and technology · 2022Article
- Use of patient specific 3D printed neurovascular phantoms to simulate mechanical thrombectomy.3D printing in medicine · 2021Article
- Investigation of Wall Shear Stress in Cardiovascular Research and in Clinical Practice-From Bench to Bedside.International journal of molecular sciences · 2021Review
- Evaluation of challenges and limitations of mechanical thrombectomy using 3D printed neurovascular phantoms.Proceedings of SPIE--the International Society for Optical Engineering · 2021Article
- Challenges in hemodynamics assessment in complex neurovascular geometries using computational fluid dynamics and benchtop flow simulation in 3D printed patient specific phantoms.Proceedings of SPIE--the International Society for Optical Engineering · 2021Article
- Clinical Applications of Patient-Specific 3D Printed Models in Cardiovascular Disease: Current Status and Future Directions.Biomolecules · 2020Review
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThree-dimensional printing (3DP) offers a unique opportunity to build flexible vascular patient-specific coronary models for device testing, treatment planning, and physiological simulations. By optimizing the 3DP design to replicate the geometrical and mechanical properties of healthy and diseased arteries, we may improve the relevance of using such models to simulate the hemodynamics of coronary disease. We developed a method to build 3DP patient specific coronary phantoms, which maintain a significant part of the coronary tree, while preserving geometrical accuracy of the atherosclerotic plaques and allows for an adjustable hydraulic resistance.
methodsCoronary computed tomography angiography (CCTA) data was used within Vitrea (Vital Images, Minnetonka, MN) cardiac analysis application for automatic segmentation of the aortic root, Left Anterior Descending (LAD), Left Circumflex (LCX), Right Coronary Artery (RCA), and calcifications. Stereolithographic (STL) files of the vasculature and calcium were imported into Autodesk Meshmixer for 3D model optimization. A base with three chambers was built and interfaced with the phantom to allow fluid collection and independent distal resistance adjustment of the RCA, LAD and LCX and branching arteries. For the 3DP we used Agilus for the arterial wall, VeroClear for the base and a Vero blend for the calcifications, respectively. Each chamber outlet allowed interface with catheters of varying lengths and diameters for simulation of hydraulic resistance of both normal and hyperemic coronary flow conditions. To demonstrate the manufacturing approach appropriateness, models were tested in flow experiments.
resultsModels were used successfully in flow experiments to simulate normal and hyperemic flow conditions. The inherent mean resistance of the chamber for the LAD, LCX, and RCA, were 1671, 1820, and 591 (dynes ∙ sec/ cm
conclusionsWe have developed a method to create complex 3D printed patient specific coronary models derived from CCTA, which allow adjustable distal capillary bed resistances. This manufacturing approach permits comprehensive coronary model development which may be used for physiologically relevant flow simulations.
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