Evidence map›Paper›PMID 32761465›Full record

ArticleJournal of community genetics2021

Hmong participants' reactions to return of individual and community pharmacogenetic research results: "A positive light for our community".

K Holzer, K A Culhane-Pera, R J Straka, Y F Wen, M Lo, K Lee, T Xiong, K Peng, J Bishop, B Thyagarajan and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of community genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  11. Review
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  13. The Identification of NovelFrontiers in pharmacology · 2022
    Article
  14. Moving Pharmacogenetics Into Practice: It's All About the Evidence!Clinical pharmacology and therapeutics · 2021
    Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

K HolzerDepartment of Genetics Cell Biology, & Genetics, University of Minnesota-Twin Cities, 6-160 Jackson Hall, 320 Church Street SE, MN, 55455, Minneapolis, USA.
K A Culhane-PeraDepartment of Genetics Cell Biology, & Genetics, University of Minnesota-Twin Cities, 6-160 Jackson Hall, 320 Church Street SE, MN, 55455, Minneapolis, USA.
R J StrakaExperimental and Clinical Pharmacology Department, College of Pharmacy, University of Minnesota-Twin Cities, Minneapolis, MN, USA.
Y F WenExperimental and Clinical Pharmacology Department, College of Pharmacy, University of Minnesota-Twin Cities, Minneapolis, MN, USA.
M LoDepartment of Genetics Cell Biology, & Genetics, University of Minnesota-Twin Cities, 6-160 Jackson Hall, 320 Church Street SE, MN, 55455, Minneapolis, USA.
K LeeDepartment of Genetics Cell Biology, & Genetics, University of Minnesota-Twin Cities, 6-160 Jackson Hall, 320 Church Street SE, MN, 55455, Minneapolis, USA.
T XiongExperimental and Clinical Pharmacology Department, College of Pharmacy, University of Minnesota-Twin Cities, Minneapolis, MN, USA.
K PengExperimental and Clinical Pharmacology Department, College of Pharmacy, University of Minnesota-Twin Cities, Minneapolis, MN, USA.
J BishopExperimental and Clinical Pharmacology Department, College of Pharmacy, University of Minnesota-Twin Cities, Minneapolis, MN, USA.
B ThyagarajanDepartment of Laboratory Medicine and Pathology, University of Minnesota-Twin Cities, MN, Minneapolis, USA.
H A ZierhutDepartment of Genetics Cell Biology, & Genetics, University of Minnesota-Twin Cities, 6-160 Jackson Hall, 320 Church Street SE, MN, 55455, Minneapolis, USA. Zier0034@umn.edu.ORCID https://orcid.org/0000-0003-1941-664X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pharmacogenetic research has historically lacked racial and ethnic diversity, limiting the application of findings to minority populations. Recent studies, including the Hmong, have gauged communities' interest in participating in genomic research and receiving their individual results. This study was conducted to create a culturally and linguistically appropriate format to return pharmacogenomic results and identify Minnesota Hmong research participants' reactions to their personal and collective results. Using a community-based participatory research approach, researchers collaborated with Hmong community members to format the pharmacogenetic disclosure process. Three focus groups were completed with 24 Hmong participants and three major themes emerged using thematic analysis. Many Hmong focus group participants viewed the results positively, finding them useful for themselves and their community as a means to optimize responses to and avoid harms from medicines. However, some participants expressed concerns about harms that the pharmacogenetic information could bring, including anxiety, misunderstanding, discrimination, exploitation, and lack of a clinician involvement in interpreting and applying the result. Many participants interpreted their results through an experiential lens, trusting their experience of medicines more than trusting genetic information, and through a cultural lens, expressing the belief that environmental factors may influence how people's bodies respond to medicines by influencing their inherited flesh and blood (roj ntsha). Lastly, participants stressed the importance of disseminating the information while acknowledging the complex linguistic, educational, and cultural factors that limit understanding of the results. Researchers, genetic counselors, pharmacists, and healthcare providers should strive to return results in meaningful ways to all members of society.

Indexed as

Community-based participatory researchGenetic testingHmongPharmacogeneticsPrecision medicine research

Identifiers

PMID32761465
PMCPMC7846627

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.