Evidence map›Paper›PMID 32761457›Full record

ReviewReviews of physiology, biochemistry and pharmacology2021

Effects of the Tumor Environment on Ion Channels: Implication for Breast Cancer Progression.

Halima Ouadid-Ahidouch, Hamid Morjani, Julie Schnipper, Alban Girault, Ahmed Ahidouch

Abstract readReview
PubMed Publisher
In one paragraph

Review in Reviews of physiology, biochemistry and pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Halima Ouadid-AhidouchLaboratory of Cellular and Molecular Physiology, UR UPJV 4667, University of Picardie Jules Verne, Amiens, France. halima.ahidouch-ouadid@u-picardie.fr.
Hamid MorjaniBioSpecT EA7506, Faculty of Pharmacy, Reims University, Reims, France.
Julie SchnipperLaboratory of Cellular and Molecular Physiology, UR UPJV 4667, University of Picardie Jules Verne, Amiens, France.
Alban GiraultLaboratory of Cellular and Molecular Physiology, UR UPJV 4667, University of Picardie Jules Verne, Amiens, France.
Ahmed AhidouchLaboratory of Cellular and Molecular Physiology, UR UPJV 4667, University of Picardie Jules Verne, Amiens, France.
Laboratoire de physiologie cellulaire et moléculaire · FRBioSpectroscopie TranslationnelleUniversité de Picardie Jules Verne · FRUniversité Ibn Zohr · MA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, it has been shown that breast cancer consists not only of neoplastic cells, but also of significant alterations in the surrounding stroma or tumor microenvironment. These alterations are now recognized as a critical element for breast cancer development and progression, as well as potential therapeutic targets. Furthermore, there is no doubt that ion channels are deregulated in breast cancer and some of which are prognostic markers of clinical outcome. Their dysregulation is also associated with aberrant signaling pathways. The number of published data on ion channels modifications by the microenvironment has significantly increased last years. Here, we summarize the state of the art on the cross talk between the tumor microenvironment and ion channels, in particular collagen 1, EGF, TGF-β, ATP, hypoxia, and pH, on the development and progression of breast cancer.

Indexed as

Breast NeoplasmsFemaleHumansIon ChannelsSignal TransductionTransforming Growth Factor betaTumor MicroenvironmentIon ChannelsTransforming Growth Factor betaATPBreast cancerCollagen 1EGFHypoxiaIon channelspHTGF-βTumor microenvironment

Identifiers

PMID32761457
OpenAlexW3047883650

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.