Evidence map›Paper›PMID 32761323›Full record

ArticleActa parasitologica2021

In Vivo Treatment with the Combination of Nitazoxanide and Flubendazole Induces Gluconeogenesis and Protein Catabolism in Taenia crassiceps cysticerci.

Nayana F Lima, Guaraciara A Picanço, Tatiane L Costa, Ruy de Souza Lino Junior, Marina C Vinaud

Abstract read
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In one paragraph

Article in Acta parasitologica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Nayana F LimaTropical Pathology and Public Health Institute, Federal University of Goias, Rua 235, s/n, Setor Universitário, Goiânia, Goiás, CEP:74605-050, Brazil.ORCID http://orcid.org/0000-0002-0775-5444
Guaraciara A PicançoTropical Pathology and Public Health Institute, Federal University of Goias, Rua 235, s/n, Setor Universitário, Goiânia, Goiás, CEP:74605-050, Brazil.ORCID http://orcid.org/0000-0002-4681-0813
Tatiane L CostaTropical Pathology and Public Health Institute, Federal University of Goias, Rua 235, s/n, Setor Universitário, Goiânia, Goiás, CEP:74605-050, Brazil.
Ruy de Souza Lino JuniorTropical Pathology and Public Health Institute, Federal University of Goias, Rua 235, s/n, Setor Universitário, Goiânia, Goiás, CEP:74605-050, Brazil.ORCID http://orcid.org/0000-0002-0572-5102
Marina C VinaudTropical Pathology and Public Health Institute, Federal University of Goias, Rua 235, s/n, Setor Universitário, Goiânia, Goiás, CEP:74605-050, Brazil. marinavinaud@gmail.com.ORCID http://orcid.org/0000-0002-6746-9191
Universidade Federal de Goiás · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 301822/2019-0Conselho Nacional de Desenvolvimento Científico e Tecnológico 302159/2016-9
6 · The paper itself

Abstract

purposeCysticercosis is the presence of Taenia solium larvae in humans or swines tissues. It is a public health problem related to bad hygienic habits and consumption of infected pork. T. crassiceps is a widely used cysticercosis experimental model. The combination of two effective drugs such as nitazoxanide (NTZ) and flubendazole (FBZ) may potentialize their effect. The aim of this study was to use biochemical analysis to determine the metabolic impact of the combination of NTZ and FBZ on cysticerci inoculated intraperitoneally in mice.

methodsBalb/c mice intraperitoneally infected with T. crassiceps cysticerci received a single oral dose NTZ/FBZ (50 mg/kg). 24 h after the treatment the cysticerci were removed, frozen and analyzed by high performance liquid chromatography regarding the detection of the following metabolic pathways: glycolysis, gluconeogenesis, homolactic fermentation, tricarboxylic acid cycle, proteins catabolism and fatty acids oxidation.

resultsThe treatment with the drugs combination induced a statistically significant increase in gluconeogenesis and in protein catabolism when compared to the control groups.

conclusionThe drugs combination is potentialized and capable of causing greater metabolic stress than the separate treatment with NTZ or FBZ, showing its potential for an alternative cysticercosis treatment.

Indexed as

CysticercusTaenia soliumAnimalsGluconeogenesisMebendazoleMiceMice, Inbred BALB CNitro CompoundsSwineThiazolesflubendazoleMebendazolenitazoxanideNitro CompoundsThiazolesDrugs combinationExperimental cysticercosisFlubendazoleMetabolismNitazoxanide

Identifiers

PMID32761323
OpenAlexW3047138460

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.