Evidence map›Paper›PMID 32761269›Full record

ArticleJournal of materials science. Materials in medicine2020

Biocompatibility evaluation of heparin-conjugated poly(ε-caprolactone) scaffolds in a rat subcutaneous implantation model.

Zeqin Xu, Zengguo Feng, Lianrui Guo, Lin Ye, Zhu Tong, Xue Geng, Cong Wang, Xin Jin, Xin Hui, Yongquan Gu

Abstract read
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In one paragraph

Article in Journal of materials science. Materials in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
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  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Zeqin XuDepartment of Vascular Surgery, Xuan Wu Hospital and Institute of Vascular Surgery, Capital Medical University, 100053, Beijing, China.
Zengguo FengSchool of Materials Science & Engineering, Beijing Institute of Technology, 100081, Beijing, China.
Lianrui GuoDepartment of Vascular Surgery, Xuan Wu Hospital and Institute of Vascular Surgery, Capital Medical University, 100053, Beijing, China.
Lin YeSchool of Materials Science & Engineering, Beijing Institute of Technology, 100081, Beijing, China.
Zhu TongDepartment of Vascular Surgery, Xuan Wu Hospital and Institute of Vascular Surgery, Capital Medical University, 100053, Beijing, China.
Xue GengSchool of Materials Science & Engineering, Beijing Institute of Technology, 100081, Beijing, China.
Cong WangDepartment of Vascular Surgery, Xuan Wu Hospital and Institute of Vascular Surgery, Capital Medical University, 100053, Beijing, China.
Xin JinSchool of Materials Science & Engineering, Beijing Institute of Technology, 100081, Beijing, China.
Xin HuiSchool of Materials Science & Engineering, Beijing Institute of Technology, 100081, Beijing, China.
Yongquan GuDepartment of Vascular Surgery, Xuan Wu Hospital and Institute of Vascular Surgery, Capital Medical University, 100053, Beijing, China. YongquanGudoctor@163.com.
Beijing Institute of Technology · CNXuan Wu Hospital of the Capital Medical University · CN

Funding

National Key R& D Program of China 2017YFC1104100
6 · The paper itself

Abstract

Vascular grafts prepared from synthetic polymers have serious shortcomings that can be resolved by surface modification, such as by immobilizing heparin. In this study, the mechanical properties, biocompatibility, anticoagulation property, and water contact angle of two heparin-conjugated poly(ε-caprolactone) scaffolds (PCL-hexamethylendiamine-heparin, PCL-HMD-H. PCL-lysine-heparin, PCL-LYS-H) were compared to identify a preferred heparin conjugation method. An evaluation of the subcutaneous tissue biocompatibility of the scaffolds demonstrated that PCL-HMD-H had better endothelial cell proliferation than the PCL-LYS-H and was therefore a promising scaffold candidate for use in vascular tissue-engineering.

Indexed as

Tissue ScaffoldsAnimalsBlood Vessel ProsthesisCell AdhesionCell MovementCell ProliferationCells, CulturedHeparinHumansHuman Umbilical Vein Endothelial CellsMaleMaterials TestingModels, AnimalPolyestersPolymersProsthesis ImplantationHeparinpolycaprolactonePolyestersPolymers

Identifiers

PMID32761269
OpenAlexW3047268797

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.