Evidence map›Paper›PMID 32761071›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2021

Human Immunodeficiency Virus (HIV) Drug Resistance, Phylogenetic Analysis, and Superinfection Among Men Who Have Sex with Men and Transgender Women in Sub-Saharan Africa: HIV Prevention Trials Network (HPTN) 075 Study.

Mariya V Sivay, Philip J Palumbo, Yinfeng Zhang, Vanessa Cummings, Xu Guo, Erica L Hamilton, Laura McKinstry, Arthur Ogendo, Noel Kayange, Ravindre Panchia and 4 more

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  7. Uptake of antiretroviral treatment and viral suppression among men who have sex with men and transgender women in sub-Saharan Africa in an observational cohort study: HPTN 075.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021
    Observational
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 9 institutions in 4 countries.

Mariya V SivayDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Philip J PalumboDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Yinfeng ZhangDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Vanessa CummingsDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Xu GuoVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Erica L HamiltonScience Facilitation Department, Family Health International 360, Durham, North Carolina, USA.
Laura McKinstryVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Arthur OgendoKenya Medical Research Institute Centers for Disease Control and Prevention, Kisumu, Kenya.
Noel KayangeDepartment of Internal Medicine, Johns Hopkins Project, College of Medicine, Malawi, Blantyre, Malawi.
Ravindre PanchiaPerinatal Human Immunodeficiency Virus Research Unit, University of the Witwatersrand, Soweto Human Immunodeficiency Virus Prevention Trials Network Clinical Research Site, Soweto, South Africa.
Karen DominguezDesmond Tutu Human Immunodeficiency Virus Centre, University of Cape Town Medical School, Cape Town, South Africa.
Ying Q ChenVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Theodorus G M SandfortHuman Immunodeficiency Virus Center for Clinical and Behavioral Studies, Columbia University, New York, New York, USA.
Susan H EshlemanDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Fred Hutch Cancer Center · USJohns Hopkins University · USJohns Hopkins Medicine · USDesmond Tutu HIV Foundation · ZAFamily Health International 360 · USKenya Medical Research Institute · KENew York Psychoanalytic Society and Institute · USUniversity of Malawi · MWUniversity of the Witwatersrand · ZA

Funding

LOC: HIV Prevention Trials NetworkUM1AI068619 · NIAID · FAMILY HEALTH INTERNATIONAL · PI Sinead Delany-Moretlwe, RAPHAEL J LANDOVITZ · 2011 to 2026
$779.5M
SDMC: HPTN 084 Pregnancy SupplementUM1AI068617 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Elizabeth Renata Brown, Deborah J Donnell · 2011 to 2026
$204.9M
LC: HIV Prevention Trials Network - Laboratory Support for the SARS-CoV-2 Seroprevalence Study (CoVPN 5002)UM1AI068613 · NIAID · JOHNS HOPKINS UNIVERSITY · PI SUSAN H ESHLEMAN, Mark A Marzinke · 2011 to 2026
$100.2M
The Statistics, Data Science, and Data Management (SDM) CoreP30MH043520 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI Claude Ann Mellins · 2003 to 2026
$48.2M
The Malawi Clinical Trials UnitUM1AI069518 · NIAID · JOHNS HOPKINS UNIVERSITY · PI JACKY M JENNINGS, TAHA E TAHA · 2012 to 2026
$43.8M
NIAID NIH HHS UM1 AI068613NIAID NIH HHS UM1 AI068617NIAID NIH HHS UM1 AI068619NIAID NIH HHS UM1 AI069518NIMH NIH HHS P30 MH043520
6 · The paper itself

Abstract

backgroundThe HIV Prevention Trials Network (HPTN) 075 study evaluated the feasibility of enrolling and retaining men who have sex with men (MSM) and transgender women (TGW) from Kenya, Malawi, and South Africa. During the study follow-up, 21 participants acquired human immunodeficiency virus (HIV) (seroconverters). We analyzed HIV subtype diversity, drug resistance, transmission dynamics, and HIV superinfection data among MSM and TGW enrolled in HPTN 075.

methodsHIV genotyping and drug resistance testing were performed for participants living with HIV who had viral loads >400 copies/mL at screening (prevalent cases, n = 124) and seroconverters (n = 21). HIV pol clusters were identified using Cluster Picker. Superinfection was assessed by a longitudinal analysis of env and pol sequences generated by next-generation sequencing.

resultsHIV genotyping was successful for 123/124 prevalent cases and all 21 seroconverters. The major HIV subtypes were A1 (Kenya) and C (Malawi and South Africa). Major drug resistance mutations were detected in samples from 21 (14.6%) of 144 participants; the most frequent mutations were K103N and M184V/I. Phylogenetic analyses identified 11 clusters (2-6 individuals). Clusters included seroconverters only (n = 1), prevalent cases and seroconverters (n = 4), and prevalent cases only (n = 6). Superinfections were identified in 1 prevalent case and 2 seroconverters. The annual incidence of superinfection was higher among seroconverters than among prevalent cases, and was higher than the rate of primary HIV infection in the cohort.

conclusionsThis report provides important insights into HIV genetic diversity, drug resistance, and superinfection among MSM and TGW in sub-Saharan Africa. These findings may help to inform future HIV prevention interventions in these high-risk groups.

Indexed as

HIV InfectionsSexual and Gender MinoritiesSuperinfectionTransgender PersonsDrug ResistanceFemaleHIVHomosexuality, MaleHumansKenyaMalawiMalePhylogenySouth AfricaHIV drug resistancemen who have sex with menphylogenetic analysissub-Saharan Africatransgender women

Identifiers

PMID32761071
PMCPMC8246905
OpenAlexW3046966614

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.