Evidence map›Paper›PMID 32761018›Full record

ArticlePhotochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology2020

Effect of low-level laser therapy on the inflammatory response in an experimental model of ventilator-induced lung injury.

Thaís Fernanda Fazza, Bruno Valle Pinheiro, Lídia Maria Carneiro da Fonseca, Luiz Philippe da Silva Sergio, Mateus Pinto Botelho, Gabrielle de Moura Lopes, Flavia de Paoli, Adenilson de Souza da Fonseca, Leda Marília Fonseca Lucinda, Maycon Moura Reboredo

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Hyperventilation worsens inflammatory lung injury in spontaneously breathing rats.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2024
    Article
  4. Article
  5. Low-power infrared laser modulates telomere length in heart tissue from an experimental model of acute lung injury.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2021
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Thaís Fernanda FazzaPulmonary Research Laboratory, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil. mayconreboredo@yahoo.com.br and Center of Reproductive Biology, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil.
Bruno Valle PinheiroPulmonary Research Laboratory, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil. mayconreboredo@yahoo.com.br and Center of Reproductive Biology, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil.ORCID http://orcid.org/0000-0002-5288-3533
Lídia Maria Carneiro da FonsecaPulmonary Research Laboratory, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil. mayconreboredo@yahoo.com.br and Center of Reproductive Biology, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil.
Luiz Philippe da Silva SergioDepartment of Biophysics and Biometry, Institute of Biology Roberto Alcantara Gomes, Rio de Janeiro State University, Rio de Janeiro, Rio de Janeiro, Brazil.ORCID http://orcid.org/0000-0001-9032-3812
Mateus Pinto BotelhoPulmonary Research Laboratory, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil. mayconreboredo@yahoo.com.br.
Gabrielle de Moura LopesPulmonary Research Laboratory, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil. mayconreboredo@yahoo.com.br.
Flavia de PaoliDepartment of Morphology, Institute of Biological Sciences, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil.
Adenilson de Souza da FonsecaDepartment of Biophysics and Biometry, Institute of Biology Roberto Alcantara Gomes, Rio de Janeiro State University, Rio de Janeiro, Rio de Janeiro, Brazil.
Leda Marília Fonseca LucindaPulmonary Research Laboratory, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil. mayconreboredo@yahoo.com.br and Center of Reproductive Biology, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil and Department of Morphology, Institute of Biological Sciences, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil.ORCID http://orcid.org/0000-0002-0975-9350
Maycon Moura ReboredoPulmonary Research Laboratory, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil. mayconreboredo@yahoo.com.br and Center of Reproductive Biology, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil.ORCID http://orcid.org/0000-0001-8155-7414
Universidade Federal de Juiz de Fora · BRUniversidade do Estado do Rio de Janeiro · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The effect of low-level laser therapy (LLLT) on an experimental model of ventilator-induced lung injury (VILI) was evaluated in this study. 24 adult Wistar rats were randomized into four groups: protective mechanical ventilation (PMV), PMV + laser, VILI and VILI + laser. The animals of the PMV and VILI groups were ventilated with tidal volumes of 6 and 35 ml kg-1, respectively, for 90 minutes. After the first 60 minutes of ventilation, the animals in the laser groups were irradiated (808 nm, 100 mW power density, 20 J cm-2 energy density, continuous emission mode, and exposure time of 5 s) and after 30 minutes of irradiation, the animals were euthanized. Lung samples were removed for morphological analysis, bronchoalveolar lavage (BAL) and real time quantitative polynucleotide chain reaction (RT-qPCR). The VILI group showed a greater acute lung injury (ALI) score with an increase in neutrophil infiltration, higher neutrophil count in the BAL fluid and greater cytokine mRNA expression compared to the PMV groups (p < 0.05). The VILI + laser group when compared to the VILI group showed a lower ALI score (0.35 ± 0.08 vs. 0.54 ± 0.13, p < 0.05), alveolar neutrophil infiltration (7.00 ± 5.73 vs. 21.50 ± 9.52, p < 0.05), total cell count (1.90 ± 0.71 vs. 4.09 ± 0.96 × 105, p < 0.05) and neutrophil count in the BAL fluid (0.60 ± 0.37 vs. 2.28 ± 0.48 × 105, p < 0.05). Moreover, LLLT induced a decrease in pro-inflammatory and an increase of anti-inflammatory mRNA levels compared to the VILI group (p < 0.05). In conclusion, LLLT was found to reduce the inflammatory response in an experimental model of VILI.

Indexed as

Disease Models, AnimalLow-Level Light TherapyAnimalsInflammationMaleRatsRats, WistarVentilator-Induced Lung Injury

Identifiers

PMID32761018
PMCPMC8047601
OpenAlexW3045473387

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.