Evidence map›Paper›PMID 32760967›Full record

ReviewChemical Society reviews2020

Microfluidic lumen-based systems for advancing tubular organ modeling.

María Virumbrales-Muñoz, José M Ayuso, Max M Gong, Mouhita Humayun, Megan K Livingston, Karina M Lugo-Cintrón, Patrick McMinn, Yasmín R Álvarez-García, David J Beebe

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Chemical Society reviews, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed.

  1. Review
  2. Article
  3. Chemical and Mechanical Regulation of Leukocyte Migration.Cold Spring Harbor perspectives in biology · 2026
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Engineering Heterogeneous Tumor Models for Biomedical Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

María Virumbrales-MuñozDepartment of Biomedical Engineering, University of Wisconsin, Madison, WI, USA. djbeebe@wisc.edu and University of Wisconsin Carbone Cancer Center, Madison, WI, USA.ORCID http://orcid.org/0000-0003-3660-8651
José M AyusoDepartment of Biomedical Engineering, University of Wisconsin, Madison, WI, USA. djbeebe@wisc.edu and University of Wisconsin Carbone Cancer Center, Madison, WI, USA and Morgridge Institute for Research, Madison, WI, USA.ORCID http://orcid.org/0000-0002-9414-1845
Max M GongDepartment of Biomedical Engineering, University of Wisconsin, Madison, WI, USA. djbeebe@wisc.edu and University of Wisconsin Carbone Cancer Center, Madison, WI, USA and Department of Biomedical Engineering, Trine University, Angola, IN, USA.ORCID http://orcid.org/0000-0003-0771-3815
Mouhita HumayunDepartment of Biomedical Engineering, University of Wisconsin, Madison, WI, USA. djbeebe@wisc.edu and University of Wisconsin Carbone Cancer Center, Madison, WI, USA.
Megan K LivingstonDepartment of Biomedical Engineering, University of Wisconsin, Madison, WI, USA. djbeebe@wisc.edu and University of Wisconsin Carbone Cancer Center, Madison, WI, USA.
Karina M Lugo-CintrónDepartment of Biomedical Engineering, University of Wisconsin, Madison, WI, USA. djbeebe@wisc.edu and University of Wisconsin Carbone Cancer Center, Madison, WI, USA.ORCID http://orcid.org/0000-0002-9661-8897
Patrick McMinnDepartment of Biomedical Engineering, University of Wisconsin, Madison, WI, USA. djbeebe@wisc.edu and University of Wisconsin Carbone Cancer Center, Madison, WI, USA.ORCID http://orcid.org/0000-0002-1914-2346
Yasmín R Álvarez-GarcíaDepartment of Biomedical Engineering, University of Wisconsin, Madison, WI, USA. djbeebe@wisc.edu and University of Wisconsin Carbone Cancer Center, Madison, WI, USA.
David J BeebeDepartment of Biomedical Engineering, University of Wisconsin, Madison, WI, USA. djbeebe@wisc.edu and University of Wisconsin Carbone Cancer Center, Madison, WI, USA and Department of Pathology & Laboratory Medicine, University of Wisconsin, Madison, WI, USA.

Funding

Project 4: Role of Receptor Tyrosine Kinase AXL in HNSCC Therapy ResistanceP50DE026787 · NIDCR · UNIVERSITY OF WISCONSIN-MADISON · PI HARARI, PAUL M · 2016 to 2020
$10.8M
Understanding cell migration through microscale in vitro modelsR01EB010039 · NIBIB · UNIVERSITY OF WISCONSIN-MADISON · PI BEEBE, DAVID J, HUTTENLOCHER, ANNA · 2011 to 2014
$1.7M
Area C: Functional microscale organotypic assays to predict patient response to anti-angiogenesis therapiesR33CA225281 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI ABEL, E JASON, BEEBE, DAVID J · 2017 to 2017
$1.5M
NCI NIH HHS L30 CA111079NCI NIH HHS R33 CA225281NIBIB NIH HHS R01 EB010039NIDCR NIH HHS P50 DE026787
6 · The paper itself

Abstract

Microfluidic lumen-based systems are microscale models that recapitulate the anatomy and physiology of tubular organs. These technologies can mimic human pathophysiology and predict drug response, having profound implications for drug discovery and development. Herein, we review progress in the development of microfluidic lumen-based models from the 2000s to the present. The core of the review discusses models for mimicking blood vessels, the respiratory tract, the gastrointestinal tract, renal tubules, and liver sinusoids, and their application to modeling organ-specific diseases. We also highlight emerging application areas, such as the lymphatic system, and close the review discussing potential future directions.

Indexed as

BiomimeticsLab-On-A-Chip DevicesBiocompatible MaterialsBiomimetic MaterialsHumansTissue EngineeringBiocompatible Materials

Identifiers

PMID32760967
PMCPMC7521761

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.