Evidence map›Paper›PMID 32760834›Full record

ArticleHeliyon2020

Hepatosplenic schistosomiasis in Zambian adults is characterized by increased liver stiffness: A nested case-control study.

Edford Sinkala, Michael Vinikoor, Alice Miyanda Siyunda, Kanekwa Zyambo, Ellen Besa, Bright Nsokolo, Gilles Wandeler, Graham R Foster, Paul Kelly

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Screening for hepatocellular carcinoma among adults with HIV/HBV co-infection in Zambia: a pilot study.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 4 countries.

Edford SinkalaDepartment of Internal Medicine, University Teaching Hospital, Lusaka, Zambia.
Michael VinikoorDepartment of Medicine, University of Alabama at Birmingham, Birmingham, USA.
Alice Miyanda SiyundaCentre for Infectious Disease Research in Zambia, Lusaka, Zambia.
Kanekwa ZyamboTropical Gastroenterology & Nutritional Group, Department of Internal Medicine, University of Zambia, Lusaka, Zambia.
Ellen BesaTropical Gastroenterology & Nutritional Group, Department of Internal Medicine, University of Zambia, Lusaka, Zambia.
Bright NsokoloDepartment of Internal Medicine, University Teaching Hospital, Lusaka, Zambia.
Gilles WandelerInstitute of Social and Preventive Medicine, University of Bern, Switzerland.
Graham R FosterBlizard Institute, Barts & The London School of Medicine, Queen Mary University of London, London, UK.
Paul KellyDepartment of Internal Medicine, University Teaching Hospital, Lusaka, Zambia.
Centre for Infectious Disease Research in Zambia · ZMQueen Mary University of London · GBUniversity of Zambia · ZMUniversity Teaching Hospital · ZMUniversity of Bern · CH

Funding

Observational Antiretroviral Studies In Southern Africa (OASIS) CollaborationU01AI069924 · NIAID · UNIVERSITAT BERN · PI Cleophas Chimbetete, Mary-Ann Davies · 2006 to 2026
$55.9M
Medical Research Council MR/K007394/1NIAID NIH HHS U01 AI069924
6 · The paper itself

Abstract

Cirrhosis commonly complicates portal hypertension worldwide but in Zambia hepatosplenic schistosomiasis (HSS) dominates as the cause of portal hypertension. We need easier and non-invasive ways to assess HSS. Transient elastography (TE), a measure of liver stiffness can diagnose liver cirrhosis. TE remains unexplored in HSS patients, who generally have normal liver parenchyma. We aimed to explore liver stiffness in HSS. This nested case control study was conducted at the University Teaching Hospital, Lusaka, Zambia between January 2015 and January 2016. We enrolled 48 adults with HSS and 22 healthy controls. We assessed liver stiffness using TE while plasma hyaluronan was used to assess liver fibrosis. Plasma tumor necrosis factor receptor 1 (TNFR1) and soluble cluster of differentiation 14 (sCD14) were used to assess inflammation. The median (interquartile range) liver stiffness was higher in patients, 9.5 kPa (7.8, 12.8) than in controls, 4.7 kPa (4.0, 5.4),

Indexed as

FibrosisHepatosplenic schistosomiasisLiver stiffnessMetabolism

Identifiers

PMID32760834
PMCPMC7393539
OpenAlexW3046178426

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.