Evidence map›Paper›PMID 32760722›Full record

ArticleFrontiers in cell and developmental biology2020

Heparanase Promotes Syndecan-1 Expression to Mediate Fibrillar Collagen and Mammographic Density in Human Breast Tissue Cultured

Xuan Huang, Gina Reye, Konstantin I Momot, Tony Blick, Thomas Lloyd, Wayne D Tilley, Theresa E Hickey, Cameron E Snell, Rachel K Okolicsanyi, Larisa M Haupt and 3 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. SDC4-rs1981429 and ATM-rs228590 may provide early biomarkers of breast cancer risk.Journal of cancer research and clinical oncology · 2023
    Article
  6. Review
  7. Review
  8. Article
  9. The Heparanase Regulatory Network in Health and Disease.International journal of molecular sciences · 2021
    Review
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

Xuan HuangInstitute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia.
Gina ReyeInstitute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia.
Konstantin I MomotInstitute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia.
Tony BlickInstitute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia.
Thomas LloydRadiology Department, Princess Alexandra Hospital, Woolloongabba, QLD, Australia.
Wayne D TilleyDame Roma Mitchell Cancer Research Laboratories, Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia.
Theresa E HickeyDame Roma Mitchell Cancer Research Laboratories, Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia.
Cameron E SnellCancer Pathology Research Group, Mater Research Institute, The University of Queensland, Brisbane, QLD, Australia.
Rachel K OkolicsanyiInstitute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia.
Larisa M HauptInstitute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia.
Vito FerroSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.
Erik W ThompsonInstitute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia.
Honor J HugoInstitute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia.
Queensland University of Technology · AUThe University of Adelaide · AUTranslational Research Institute · AUMater Adult Hospital · AUPrincess Alexandra Hospital · AUThe University of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mammographic density (MD) is a strong and independent factor for breast cancer (BC) risk and is increasingly associated with BC progression. We have previously shown in mice that high MD, which is characterized by the preponderance of a fibrous stroma, facilitates BC xenograft growth and metastasis. This stroma is rich in extracellular matrix (ECM) factors, including heparan sulfate proteoglycans (HSPGs), such as the BC-associated syndecan-1 (SDC1). These proteoglycans tether growth factors, which are released by heparanase (HPSE). MD is positively associated with estrogen exposure and, in cell models, estrogen has been implicated in the upregulation of HPSE, the activity of which promotes SDC expression. Herein we describe a novel measurement approach (single-sided NMR) using a patient-derived explant (PDE) model of normal human (female) mammary tissue cultured

Indexed as

breast cancerheparanasemammographic densityNMRsyndecan-1

Identifiers

PMID32760722
PMCPMC7373078
OpenAlexW3043629054

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.