Evidence map›Paper›PMID 32760714›Full record

ArticleFrontiers in bioengineering and biotechnology2020

CRISPR/Cas12a Mediated Genome Editing Enhances

Zhanqi Dong, Qi Qin, Zhigang Hu, Xinling Zhang, Jianghao Miao, Liang Huang, Peng Chen, Cheng Lu, Minhui Pan

Open access · goldAbstract read
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 37 citations in OpenAlex.

  1. Review
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  5. Comparison of CRISPR-MAD7 and CRISPR-Cas9 for Gene Disruptions inJournal of fungi (Basel, Switzerland) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Zhanqi DongState Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, China.
Qi QinState Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, China.
Zhigang HuState Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, China.
Xinling ZhangState Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, China.
Jianghao MiaoState Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, China.
Liang HuangState Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, China.
Peng ChenState Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, China.
Cheng LuState Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, China.
Minhui PanState Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, China.
State Key Laboratory of Silkworm Genomic BiologySouthwest University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CRISPR/Cas12a (Cpf1) is a single RNA-guided endonuclease that provides new opportunities for targeted genome engineering through the CRISPR/Cas9 system. Only AsCas12a has been developed for insect genome editing, and the novel Cas12a orthologs nucleases and editing efficiency require more study on insects. We compared three Cas12a orthologs nucleases, AsCas12a, FnCas12a, and LbCas12a, for their editing efficiencies and antiviral abilities. The three Cas12a efficiently edited the

Indexed as

antiviral therapyBmNPVBombyx moriCRISPR/Cas12agenome editing

Identifiers

PMID32760714
PMCPMC7373793
OpenAlexW3043414469

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.