Evidence map›Paper›PMID 32760600›Full record

ArticleOman medical journal2020

Association of rs12487066, rs12044852, rs10735781, rs3135388, rs6897932, rs1321172, rs10492972, and rs9657904 Polymorphisms with Multiple Sclerosis in Iranian Population.

Takavar Razavian, Mahdieh Ebrahimi Shakib, Kurosh Gharagozli, Hossein Maghsoudi, Seyed Kazem Bidoki, Soha Sadeghi, Massoud Houshmand

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Article in Oman medical journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Takavar RazavianDepartment of Biology, Shahr Rey Branch, Payame Noor University, Tehran, Iran.
Mahdieh Ebrahimi ShakibDepartment of Cellular and Molecular Biology, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran.
Kurosh GharagozliDepartment of Neurological Diseases, Shahid Beheshti University of Medical Sciences Branch, Tehran, Iran.
Hossein MaghsoudiDepartment of Biotechnology, Shahr Rey Branch, Payame Noor University, Tehran, Iran.
Seyed Kazem BidokiDepartment of Biochemistry and Biotechnology, East Tehran Centre, Payame Noor University, Tehran, Iran.
Soha SadeghiDepartment of Human Biology and Medical Genetics, Sapienza University, Rome, Italy.
Massoud HoushmandDepartment of Medical Genetics, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesMultiple sclerosis (MS) is a chronic disease of the central nervous system. The pathogenesis of MS is best described by a multifactorial model incorporating interactions between genetic and environmental factors with the role of genetic factors increasingly taken into account. The main goal of this study was to investigate the associations of rs12487066, rs12044852, rs10735781, rs3135388, rs6897932, rs1321172, rs10492972, and rs9657904 polymorphisms with MS in the Iranian population.

methodsA total of 83 patients with MS (82.0% female and 18.0% male; mean age = 35.2±8.6 years) and 100 physically and mentally healthy subjects (81.0% female and 19.0% male; mean age = 40.4±6.4 years) were selected using convenient sampling. A 5 mL blood sample was taken from each case and control patient. We used the tetra-primer ARMS-PCR method to genotype the desired polymorphisms. The associations between polymorphisms and the disease were studied based on codominant, dominant, recessive, and overdominant models.

resultsThe rs10735781 polymorphism was codominantly (

conclusionsWe found an association between the rs10735781 and rs6897932 polymorphisms on the

Indexed as

GenotypeIranMultiple SclerosisPolymerase Chain ReactionPolymorphism, Single Nucleotide

Identifiers

PMID32760600
PMCPMC7374718

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