Evidence map›Paper›PMID 32760596›Full record

ArticleInternational journal of retina and vitreous2020

Successful growth of fresh retinoblastoma cells in chorioallantoic membrane.

Silvia L Fialho, Bárbara R Silvestrini, Juliana Vieira, Mayara R B Paiva, Luciana M Silva, Fernando Chahud, Armando Silva-Cunha, Zelia M Correa, Rodrigo Jorge

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of retina and vitreous, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Histone Deacetylases in Retinoblastoma.International journal of molecular sciences · 2024
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Silvia L FialhoPharmaceutical Research and Development, Ezequiel Dias Foundation, Belo Horizonte, Brazil.
Bárbara R SilvestriniPharmaceutical Research and Development, Ezequiel Dias Foundation, Belo Horizonte, Brazil.
Juliana VieiraDepartment of Ophthalmology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Mayara R B PaivaPharmaceutical Research and Development, Ezequiel Dias Foundation, Belo Horizonte, Brazil.
Luciana M SilvaDepartment of Cell Biology, Ezequiel Dias Foundation, Belo Horizonte, Minas Gerais Brazil.
Fernando ChahudDepartment of Pathology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Armando Silva-CunhaSchool of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Zelia M CorreaDepartment of Ophthalmology, Wilmer Eye Institute, Johns Hopkins Medicine, Baltimore, MD USA.ORCID 0000-0003-2946-3757
Rodrigo JorgeDepartment of Ophthalmology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The authors developed a retinoblastoma model using fresh harvested cells from an enucleated eye that were transplanted in chick embryos (chorioallantoic membrane model). The transplanted embryos were treated with escalating doses of Melphalan. This exploratory model was developed with the goal of testing drug sensitivity. Our findings suggest this tumor model could be employed to personalize treatment for patients with retinoblastoma, especially those with bilateral and more refractory disease.

Indexed as

CAM assayChorioallantoic membraneRetinoblastomaTumor models

Identifiers

PMID32760596
PMCPMC7391810

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.