ArticleBiotechnology for biofuels2020
High production of triterpenoids in
Article in Biotechnology for biofuels, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 62 citations in OpenAlex.
- Systematic enzyme and cofactor engineering for efficient ursolic acid biosynthesis inSynthetic and systems biotechnology · 2027Article
- Physiological metabolic analysis and process optimization of hypoxia in promoting coenzyme QSynthetic and systems biotechnology · 2026Article
- Effects and Adaptive Responses of Sulfate-Reducing Biochemical System to Acid Stress.Biomolecules · 2026Article
- Strategic selection of microbial cell factories for sustainable and application-specific terpenoid production.Frontiers in bioengineering and biotechnology · 2026Review
- Combined metabolic and enzymatic engineering forSynthetic and systems biotechnology · 2025Article
- Adaptive laboratory evolution of Blakeslea trispora under acetoacetanilide stress leads to enhanced β-carotene biosynthesis.Scientific reports · 2025Article
- Optimizing longifolene production inSynthetic and systems biotechnology · 2025Article
- Review
- Recent trends in the elucidation of complex triterpene biosynthetic pathways in horticultural trees.Horticulture research · 2025Article
- Exploration of In Situ Extraction for Enhanced Triterpenoid Production by Saccharomyces cerevisiae.Microbial biotechnology · 2024Article
- Boosting Geranyl Diphosphate Synthesis for Linalool Production in Engineered Yarrowia lipolytica.Applied biochemistry and biotechnology · 2024Article
- Progress in the Metabolic Engineering ofBiodesign research · 2024Review
- Boosting the epoxidation of squalene to produce triterpenoids in Saccharomyces cerevisiae.Biotechnology for biofuels and bioproducts · 2023Article
- Engineering ofMetabolic engineering communications · 2022Review
- Enhanced production of amyrin in Yarrowia lipolytica using a combinatorial protein and metabolic engineering approach.Microbial cell factories · 2022Article
- Optimization of microbial cell factories for astaxanthin production: Biosynthesis and regulations, engineering strategies and fermentation optimization strategies.Synthetic and systems biotechnology · 2022Review
- Compartmentalization and transporter engineering strategies for terpenoid synthesis.Microbial cell factories · 2022Review
- Highly efficient biosynthesis of β-caryophyllene with a new sesquiterpene synthase from tobacco.Biotechnology for biofuels and bioproducts · 2022Article
- Selective biosynthesis of retinol in S. cerevisiae.Bioresources and bioprocessing · 2022Article
- Transporter Engineering in Microbial Cell Factory Boosts Biomanufacturing Capacity.Biodesign research · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLupeol exhibits novel physiological and pharmacological activities, such as anticancer and immunity-enhancing activities. However, cytotoxicity remains a challenge for triterpenoid overproduction in microbial cell factories. As lipophilic and relatively small molecular compounds, triterpenes are generally secreted into the extracellular space. The effect of increasing triterpene efflux on the synthesis capacity remains unknown.
resultsIn this study, we developed a strategy to enhance triterpene efflux through manipulation of lipid components in
conclusionsIn conclusion, we successfully created a high-yield lupeol-producing strain via lipid manipulation. We demonstrated that the enhancement of lupeol efflux and synthesis capacity was induced by the increased UFA content and elongated cell morphology. Our study provides a novel strategy to promote the biosynthesis of valuable but toxic products in microbial cell factories.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.