Evidence map›Paper›PMID 32760406›Full record

ReviewFrontiers in immunology2020

An Ancient Molecular Arms Race:

Gabrielle Keb, Kenneth A Fields

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Gabrielle KebDepartment of Microbiology, Immunology & Molecular Genetics, University of Kentucky College of Medicine, Lexington, KY, United States.
Kenneth A FieldsDepartment of Microbiology, Immunology & Molecular Genetics, University of Kentucky College of Medicine, Lexington, KY, United States.
University of Kentucky · US

Funding

The role of Perforin-2 in Chlamydia pathogenesisR56AI117876 · NIAID · UNIVERSITY OF KENTUCKY · PI FIELDS, KENNETH A, PLANO, GREGORY V · 2015 to 2015
$383k
Chlamydia trachomatis Secreted Effector Proteins: Infection Properties and Identification of Host TargetsF31AI147417 · NIAID · UNIVERSITY OF KENTUCKY · PI KEB, GABRIELLE · 2019 to 2021
$74k
NIAID NIH HHS F31 AI147417NIAID NIH HHS R56 AI117876
6 · The paper itself

Abstract

Dynamic interactions that govern the balance between host and pathogen determine the outcome of infection and are shaped by evolutionary pressures. Eukaryotic hosts have evolved elaborate and formidable defense mechanisms that provide the basis for innate and adaptive immunity. Proteins containing a membrane attack complex/Perforin (MACPF) domain represent an important class of immune effectors. These pore-forming proteins induce cell killing by targeting microbial or host membranes. Intracellular bacteria can be shielded from MACPF-mediated killing, and

Indexed as

AnimalsBiological EvolutionChlamydiaChlamydia InfectionsComplement C9Complement Membrane Attack ComplexHost-Pathogen InteractionsHumansImmunity, InnatePerforinComplement C9Complement Membrane Attack ComplexPerforinevolutionimmunityobligate intracellularpathogenesispore-forming

Identifiers

PMID32760406
PMCPMC7371996
OpenAlexW3042615179

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.