ArticleFrontiers in physiology2020
Excessive Erythrocytosis and Chronic Mountain Sickness in Dwellers of the Highest City in the World.
Article in Frontiers in physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Mountain sickness in altitude inhabitants of Latin America: A systematic review and meta-analysis.PloS one · 2024Pooled it
- Effect of chronic high-altitude hypoxia on retinal vascular phenotype, choroidal and retinal vasoreactivity in Peruvian highlanders.Experimental physiology · 2026Article
- Resting and Physical Activity Energy Expenditure Across an Altitudinal Gradient: An Adjusted Analysis.Oxygen (Basel, Switzerland) · 2026Article
- Higher Prevalence of Cognitive Impairment in Residents of High-Altitude Regions.Oxygen (Basel, Switzerland) · 2026Article
- High‑altitude polycythemia: Unveiling the molecular landscape beyond erythropoietin (Review).International journal of molecular medicine · 2026Review
- Review
- Excessive erythrocytosis and the hypertensive phenotype at high altitude: emerging evidence and unresolved questions.Frontiers in cardiovascular medicine · 2026Review
- Olfactory Decline in Elderly at High Altitudes: A Narrative Review.International journal of general medicine · 2026Review
- Addressing Anemia in High-Altitude Populations: Global Impact, Prevalence, Challenges, and Potential Solutions.American journal of hematology · 2025Review
- Adjustment Criteria for Air-Quality Standards by Altitude: A Scoping Review with Regulatory Overview.International journal of environmental research and public health · 2025Article
- Redefining chronic mountain sickness: insights from high-altitude research and clinical experience.Medical review (2021) · 2025Review
- Association betweenFrontiers in medicine · 2025Article
- Life destiny of erythrocyte in high altitude erythrocytosis: mechanisms underlying the progression from physiological (moderate) to pathological (excessive) high-altitude erythrocytosis.Frontiers in genetics · 2025Review
- Micro- and macrovascular function in the highest city in the world: a cross sectional study.Lancet regional health. Americas · 2024Article
- Performance in the Six-Minute Walking Test Does Not Discriminate Excessive Erythrocytosis Patients in a Severe Hypoxic Environment.International journal of environmental research and public health · 2024Article
- COVID-19 and silent hypoxemia in a minimal closed-loop model of the respiratory rhythm generator.Biological cybernetics · 2024Article
- Cerebral homeostasis and orthostatic responses in residents of the highest city in the world.Scientific reports · 2024Article
- Altitude illnesses.Nature reviews. Disease primers · 2024Review
- Are coagulation profiles in Andean highlanders with excessive erythrocytosis favouring hypercoagulability?Experimental physiology · 2024Article
- FunctionalScience advances · 2024Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhile millions of people are living permanently at high altitude (>2,500 m) worldwide, the mechanisms underlying their tolerance to chronic hypoxia and those responsible for the occurrence of chronic mountain sickness (CMS) remain to be elucidated. Excessive erythrocytosis (EE) is thought to be the main mechanism responsible for CMS symptoms and is included in the definition of CMS, but the precise interplay between EE and symptoms of CMS requires further investigations.
methodsThe present study benefits from an exceptional dataset coming from 1,594 dwellers of La Rinconada, the highest city in the world (5,100-5,300 m). Based on individual clinical characteristics, subjects were categorized according to the presence of EE and CMS diagnosis, based on current guidelines.
resultsIn this population of relatively young [32 (23; 39) years] highlanders residing in La Rinconada for only a few years [3 (2; 5) years], the internal prevalence of EE (44%) was high, whereas the internal prevalence of CMS (14%) was similar compared to previous reports in highlander populations living at lower altitude (∼4,000 m) in the Andes. Individuals with EE reported less symptoms compared to individuals with lower hematocrit values. Multivariable analysis revealed that age and sex are the main factors associated with EE, whereas age, hematocrit and number of years living at La Rinconada are factors associated with CMS symptoms.
conclusionIn this specific population of La Rinconada, high hematocrit values were observed but were associated with limited symptoms. These results raise important questions regarding the definition of EE and CMS and their underlying mechanisms in high-altitude populations.
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