Evidence map›Paper›PMID 32760120›Full record

ArticlePLoS pathogens2020

Synthetic DNA and biosecurity: Nuances of predicting pathogenicity and the impetus for novel computational approaches for screening oligonucleotides.

R A Leo Elworth, Christian Diaz, Jing Yang, Paul de Figueiredo, Krista Ternus, Todd Treangen

Abstract read
In one paragraph

Article in PLoS pathogens, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. ADAPT: a programme for the advanced detection of AI-enabled pathogenic threats.Frontiers in bioengineering and biotechnology · 2026
    Article
  3. Review
  4. Screening State of Play: The Biosecurity Practices of Synthetic DNA Providers.Applied biosafety : journal of the American Biological Safety Association · 2024
    Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

R A Leo ElworthDepartment of Computer Science, Rice University, Houston, Texas, United States of America.ORCID 0000-0002-3945-0661
Christian DiazDepartment of Computer Science, Rice University, Houston, Texas, United States of America.
Jing YangDepartment of Microbial Pathogenesis and Immunology, Texas A&M Health Science Center, Bryan, Texas, United States of America.
Paul de FigueiredoDepartment of Microbial Pathogenesis and Immunology, Texas A&M Health Science Center, Bryan, Texas, United States of America.
Krista TernusSignature Science, LLC, Austin, Texas, United States of America.ORCID 0000-0003-1138-5308
Todd TreangenDepartment of Computer Science, Rice University, Houston, Texas, United States of America.ORCID 0000-0002-3760-564X

Funding

Development of a High-Throughput Microfluidics-Enabled Functional Assay for Rapidly Identifying Neutralizing AntibodiesR01AI141607 · NIAID · UNIVERSITY OF MISSOURI-COLUMBIA · PI DE FIGUEIREDO, PAUL, HAN, ARUM · 2019 to 2023
$3.4M
Accelerating discovery of neutralizing paratopes with Functional Antibody Screening TechnologyR21AI139738 · NIAID · TEXAS A&M UNIVERSITY · PI HAN, ARUM · 2020 to 2021
$415k
MIRROR: A Chip-Scale Mid-IR Ring Resonance System for On-the-fly Reporting of AnalytesR21GM132705 · NIGMS · TEXAS ENGINEERING EXPERIMENT STATION · PI HAN, ARUM · 2019 to 2020
$392k
NIAID NIH HHS R01 AI141607NIAID NIH HHS R21 AI139738NIGMS NIH HHS R21 GM132705
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsComputational BiologyDNAHost-Pathogen InteractionsHumansOligonucleotidesVirulenceVirulence FactorsDNAOligonucleotidesVirulence Factors

Identifiers

PMID32760120
PMCPMC7410204

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.